1022-66-8

Basic information

• Product Name: 3-PHENYL-3,4-DIHYDROQUINOLIN-2(1H)-ONE
• Synonyms: 3-PHENYL-3,4-DIHYDROQUINOLIN-2(1H)-ONE
• CAS NO: 1022-66-8
• Molecular Formula: C₁₅H₁₃NO
• Molecular Weight: 223.27
• Mol File: 1022-66-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 178 °C
• Boiling Point: 407.8±44.0 °C(Predicted)
• Appearance: /
• Density: 1.156±0.06 g/cm3(Predicted)
• PKA: 14.32±0.40(Predicted)
• CAS DataBase Reference: 3-PHENYL-3,4-DIHYDROQUINOLIN-2(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYL-3,4-DIHYDROQUINOLIN-2(1H)-ONE(1022-66-8)
• EPA Substance Registry System: 3-PHENYL-3,4-DIHYDROQUINOLIN-2(1H)-ONE(1022-66-8)

Safety Data

• Hazardous Substances Data: 1022-66-8(Hazardous Substances Data)

Usage

General Description

3-PHENYL-3,4-DIHYDROQUINOLIN-2(1H)-ONE is a chemical compound with a molecular formula C16H13NO. It is a quinolone derivative with a phenyl group attached to the third carbon of the quinolone ring. 3-PHENYL-3,4-DIHYDROQUINOLIN-2(1H)-ONE has potential applications in medicinal chemistry and drug development due to its structural features and pharmacological properties. It can act as a building block for the synthesis of various pharmaceutical and biologically active compounds. Its unique molecular structure makes it a valuable material for research in the fields of organic chemistry, pharmaceuticals, and drug discovery.

Upstream product

• 19319-35-8 (E)-2-phenyl-3-(2-nitrophenyl)propenoic acid 
• 552-89-6 2-nitro-benzaldehyde 
• 103-82-2 phenylacetic acid 
• 64859-23-0 α-phenylacrylanilide 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 14485-09-7 2-phenylacrylamide 
• 1865-29-8 2-phenyl-acrylic acid methyl ester 
• 365-33-3 2-nitrobenzenediazonium tetrafluoroborate 
• 615-43-0 2-iodophenylamine 
• 22286-82-4 2-phenyl-acrylic acid ethyl ester 
• 201230-82-2 carbon monoxide 
• 27652-35-3 (E)-2-styrylaniline 
• 19393-14-7 (Z)-3-(2-nitrophenyl)-2-phenylprop-2-enoic acid 

Downstream Products

• 27771-46-6 4-phenyl-5H-oxazolo[3,2-a]quinoline-1,2-dione 
• 57876-69-4 2-chloro-3-methyl-quinoline 
• 38035-81-3 3-phenyl-1H-quinolin-2-one 
• 2859-30-5 2-chloro-3-phenyl-quinoline 
• 113093-16-6 6-Bromo-3-chloro-3-phenyl-3,4-dihydro-1H-quinolin-2-one 
• 113092-97-0 3-Phenyl-2-piperazin-1-yl-quinoline 
• 113092-98-1 2-(4-Methyl-piperazin-1-yl)-3-phenyl-quinoline 
• 113092-99-2 2-(4-Ethyl-piperazin-1-yl)-3-phenyl-quinoline 
• 113093-01-9 6-Bromo-2-(4-methyl-piperazin-1-yl)-3-phenyl-quinoline 
• 113093-00-8 2-[4-(3-Phenyl-quinolin-2-yl)-piperazin-1-yl]-ethanol 
• 113093-02-0 2-[4-(6-Bromo-3-phenyl-quinolin-2-yl)-piperazin-1-yl]-ethanol 
• 110486-57-2 6-bromo-3-phenylquinolin-2(1H)-one 
• 85274-48-2 6-bromo-2-chloro-3-phenylquinoline 
• 1356541-55-3 C₁₈H₁₇NO₃ 

Relevant articles and documents

Regio- And Stereoselective Synthesis of Diverse 3,4-Dihydro-2-quinolones through Catalytic Hydrative Cyclization of Imine- And Carbonyl-Ynamides with Water

Transition-metal-catalyzed alkyne hydration reaction has attracted considerable interest in the past decades because this approach would lead to the facile and efficient formation of synthetically useful carbonyls. However, transition-metal-catalyzed alky

Multicomponent multicatalyst reactions (MC)2R: One-pot synthesis of 3,4-dihydroquinolinones

A Rh/Pd/Cu catalyst system led to an efficient synthesis of dihydroquinolinones in one-pot, two operations. The reaction features the first triple metal-catalyzed transformations in one reaction vessel, without any intermediate workup. The conjugate-addition/amidation/amidation reaction sequence is highly modular, divergent, and practical.

Preparation of 2-Quinolones by sequential heck reduction-cyclization (HRC) reactions by using a multitask palladium catalyst

One-pot sequential Heck reduction-cyclization (HRC) reactions leading to the synthesis of substituted 2-quinolones have been developed by using a heterogeneous or mixed homogeneous/heterogeneous multitask palladium catalyst with charcoal as a support. The whole sequence occurs under very mild conditions without the need for additives (ligand or base) by taking advantage of the high reactivity of aryldiazonium salts as "super electrophiles". Recycling experiments showed that the reused heterogeneous Pd°/C catalyst was not able to promote another HRC sequence but was, however, still highly active for hydrogenation, hydrodehalogenation, as well as hydrogenolysis reactions.