193970-57-9

Upstream product

• 193970-21-7 [(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-acetaldehyde 
• 221455-79-4 tert-Butyl-[(2R,4S,5R)-4-(2-iodo-ethyl)-2-phenyl-[1,3]dioxan-5-yloxy]-dimethyl-silane 
• 221455-78-3 2-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethanol 
• 250226-93-8 (E)-4-((2R,4S,5R)-5-Hydroxy-2-phenyl-[1,3]dioxan-4-yl)-but-2-enoic acid methyl ester 
• 213815-23-7 (E)-4-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-but-2-enoic acid methyl ester 
• 78606-78-7 methyl (E,5S,6R)-5,6,7-trihydroxyhept-2-enoate 
• 22900-10-3 2-deoxy-D-ribose 
• 121620-34-6 (R)-3,3-bis(ethylthio)tetrahydro-2H-pyran-2-carboxaldehyde 

Downstream Products

• 193970-59-1 (2R,4S,5R)-4-[(Z)-3-((R)-3,3-Bis-ethylsulfanyl-tetrahydro-pyran-2-yl)-allyl]-2-phenyl-[1,3]dioxan-5-ol 
• 221379-82-4 2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester 
• 221379-83-5 (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-Bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-ol 

Relevant academic research and scientific papers

Total synthesis of brevetoxin A: Part 2: Second generation strategy and construction of EFGH model system

Our second generation strategy for the total synthesis of brevetoxin A involved dissection of the molecule at the ring F oxocene. Synthetically, the F ring formation was expected to occur through Wittig coupling of requisite polycyclic fragments 2 and 3,