221455-79-4

Upstream product

• 221455-78-3 2-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethanol 
• 78606-78-7 methyl (E,5S,6R)-5,6,7-trihydroxyhept-2-enoate 
• 213815-23-7 (E)-4-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-but-2-enoic acid methyl ester 
• 250226-93-8 (E)-4-((2R,4S,5R)-5-Hydroxy-2-phenyl-[1,3]dioxan-4-yl)-but-2-enoic acid methyl ester 
• 193970-21-7 [(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-acetaldehyde 
• 22900-10-3 2-deoxy-D-ribose 

Downstream Products

• 486394-99-4 tert-Butyl-[(2R,4S,5R)-4-(2-[1,3]dithian-2-yl-ethyl)-2-phenyl-[1,3]dioxan-5-yloxy]-dimethyl-silane 
• 221379-82-4 2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester 
• 221379-83-5 (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-Bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-ol 
• 193970-57-9 {(2R,4S,5R)-4-[(Z)-3-((R)-3,3-Bis-ethylsulfanyl-tetrahydro-pyran-2-yl)-allyl]-2-phenyl-[1,3]dioxan-5-yloxy}-tert-butyl-dimethyl-silane 
• 193970-59-1 (2R,4S,5R)-4-[(Z)-3-((R)-3,3-Bis-ethylsulfanyl-tetrahydro-pyran-2-yl)-allyl]-2-phenyl-[1,3]dioxan-5-ol 
• 486394-81-4 (E)-4-((4aR,5aS,6aR,8S,9R,10aS,11aR,13aS)-2,2,9,10a-Tetramethyl-9-trimethylsilanyloxy-dodecahydro-1,3,5,7,11-pentaoxa-benzo[4,5]cyclohepta[1,2-b]naphthalen-8-yl)-but-2-enoic acid benzyl ester 
• 486394-97-2 (E)-4-((4aR,5aS,6aR,8S,9R,10aS,11aR,13aS)-9-Hydroxy-2,2,9,10a-tetramethyl-dodecahydro-1,3,5,7,11-pentaoxa-benzo[4,5]cyclohepta[1,2-b]naphthalen-8-yl)-but-2-enoic acid benzyl ester 
• 486394-75-6 (E)-4-[(2R,4aR,6S,7R,9aS)-7-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-6-yl]-2-methyl-but-2-enoic acid ethyl ester 
• 486394-76-7 {(2R,3R)-3-[(2R,4aR,6S,7R,9aS)-7-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-6-ylmethyl]-2-methyl-oxiranyl}-methanol 
• 486395-02-2 (E)-4-[(2R,4aR,6S,7R,9aS)-7-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-6-yl]-2-methyl-but-2-en-1-ol 
• 486394-77-8 tert-Butyl-dimethyl-[(2R,4aR,6S,7R,9aS)-6-((2R,3R)-3-methyl-3-vinyl-oxiranylmethyl)-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-yloxy]-silane 
• 486394-74-5 (E)-4-((2R,4aR,6S,7R,9aS)-7-Hydroxy-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-6-yl)-2-methyl-but-2-enoic acid ethyl ester 
• 486395-00-0 (E)-3-[(2R,4S,5R)-4-(2-[1,3]Dithian-2-yl-ethyl)-2-phenyl-[1,3]dioxan-5-yloxy]-acrylic acid ethyl ester 
• 486394-70-1 (2R,4aR,5aS,7R,8S,9aR,11aS)-8-Methyl-2-phenyl-8-vinyl-decahydro-1,3,5,9-tetraoxa-dibenzo[a,d]cyclohepten-7-ol 

Relevant academic research and scientific papers

Total synthesis of (-)-gambierol

The first total synthesis of (-)-gambierol (1), a marine polycyclic ether toxin, has been achieved. Key features of the successful synthesis include (1) a convergent union of the ABC and EFGH ring fragments (5 and 6, respectively) via our developed B-alky

Total synthesis of brevetoxin A: Part 2: Second generation strategy and construction of EFGH model system

Our second generation strategy for the total synthesis of brevetoxin A involved dissection of the molecule at the ring F oxocene. Synthetically, the F ring formation was expected to occur through Wittig coupling of requisite polycyclic fragments 2 and 3,