51363-00-9

Basic information

• Product Name: 4-(PYRID-2-YLOXY)BENZOIC ACID
• Synonyms: 4-(PYRID-2-YLOXY)BENZOIC ACID;4-(Pyridin-2-yloxy)benzoic acid
• CAS NO: 51363-00-9
• Molecular Formula: C₁₂H₉NO₃
• Molecular Weight: 215.2
• Mol File: 51363-00-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 174 °C
• Boiling Point: 391.208 °C at 760 mmHg
• Flash Point: 190.396 °C
• Appearance: /
• Density: 1.298 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: 4-(PYRID-2-YLOXY)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PYRID-2-YLOXY)BENZOIC ACID(51363-00-9)
• EPA Substance Registry System: 4-(PYRID-2-YLOXY)BENZOIC ACID(51363-00-9)

Safety Data

• Hazardous Substances Data: 51363-00-9(Hazardous Substances Data)

Usage

General Description

4-(Pyrid-2-yloxy)benzoic acid is a chemical compound with the molecular formula C13H9NO3. It is a derivative of benzoic acid and contains a pyridine ring attached to the benzene ring through an ether linkage. 4-(Pyrid-2-yloxy)benzoic acid has potential applications in the field of pharmaceuticals and agrochemicals due to its pharmacological properties. It can act as a building block in the synthesis of various biologically active compounds. The presence of the pyridine ring also gives this compound unique properties, making it useful for various research and industrial applications.

InChI:InChI=1/C12H9NO3/c14-12(15)9-4-6-10(7-5-9)16-11-3-1-2-8-13-11/h1-8H,(H,14,15)

Upstream product

• 109-09-1 2-chloropyridine 
• 106-41-2 4-bromo-phenol 
• 89488-29-9 2-bromo-4-methoxypyridine 
• 153653-00-0 2-<(4-methoxycarbonylphenyl)oxy>pyridine 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 109-04-6 2-bromo-pyridine 
• 53330-48-6 4-(pyridin-2-yloxy)benzoic acid ethyl ester 

Downstream Products

• 194017-70-4 2-(4-Hydroxymethylphenoxy)pyridine 
• 51363-01-0 4-(pyridin-2-yloxy)benzoyl chloride 
• 1442120-97-9 N-(2-methoxyethyl)-4-methyl-2-({1-[4-(pyridin-2-yloxy)benzoyl]piperidin-4-yl}methyl)-2H-indazole-5-carboxamide 

Relevant articles and documents

Synthesis and structure–activity relationship of N-(piperidin-4-yl)benzamide derivatives as activators of hypoxia-inducible factor 1 pathways

Guided by bioisosterism and pharmacokinetic parameters, we designed and synthesized a series of novel benzamide derivatives. Preliminary in vitro studies indicated that compounds 10b and 10j show significant inhibitory bioactivity in HepG2 cells (IC50 values of 0.12 and 0.13?μM, respectively). Compounds 10b and 10j induced the expression of HIF-1α protein and downstream target gene p21, and upregulated the expression of cleaved caspase-3 to promote tumor cells apoptosis.

Rhodium-catalyzed borylation of aryl 2-pyridyl ethers through cleavage of the carbon-oxygen bond: Borylative removal of the directing group

The rhodium-catalyzed reaction of aryl 2-pyridyl ethers with a diboron reagent results in the formation of arylboronic acid derivatives via activation of the C(aryl)-O bonds. The straightforward synthesis of 1,2-disubstituted arenes was enabled through catalytic ortho C-H bond functionalization directed by the 2-pyridyloxy group followed by substitution of this group with a boryl group. Several control experiments revealed that the presence of a sp2 nitrogen atom at the 2-position of the substrate and the use of a boron-based reagent were crucial for the activation of the relatively inert C(aryl)-O bond of aryl 2-pyridyl ethers.

SUBSTITUTED CARBOXYLIC ACID DERIVATIVES

The invention provides novel substituted carboxylic acid derivatives that bind to receptor as ligands of human peroxisome proliferator-activated receptor (PPAR) to activate it and exhibit potent triglyceride-lowering action, cholesterol-lowering action an