194032-43-4

Basic information

• Product Name: (2S,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: (2S,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(2S,5S)-1-N-BOC-2,5-DIMETHYLPIPERAZINE;(2R,5R)-1-N-BOC-2,5-DIMETHYLPIPERAZINE;(2R,5R)-1-Boc-2,5-diMethylpiperazine-HCl;(2R,5R)-tert-Butyl 2,5-diMethylpiperazine-1-carboxylate hydrochloride;(2R,5R)-2,5-Dimethyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester;(2R,5R)-rel-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate
• CAS NO: 194032-43-4
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.30458
• Mol File: 194032-43-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 279.7℃
• Flash Point: 123.0℃
• Appearance: /
• Density: 0.970
• Vapor Pressure: 0.00394mmHg at 25°C
• Refractive Index: 1.452
• PKA: 8.55±0.60(Predicted)
• CAS DataBase Reference: (2S,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(194032-43-4)
• EPA Substance Registry System: (2S,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(194032-43-4)

Safety Data

• Hazardous Substances Data: 194032-43-4(Hazardous Substances Data)

Usage

General Description

(2S,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is a chemical compound with the molecular formula C13H24N2O2. It is a tert-butyl ester derivative of (2S,5S)-2,5-dimethylpiperazine-1-carboxylic acid, which is an acidic amino acid commonly used in the synthesis of peptides and pharmaceuticals. The tert-butyl ester group is often used to protect the carboxylic acid functionality and facilitate its incorporation into larger molecules. (2S,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER may be used as an intermediate in organic synthesis or as a building block in the preparation of pharmaceutical compounds.

InChI:InChI=1/C11H22N2O2/c1-8-7-13(9(2)6-12-8)10(14)15-11(3,4)5/h8-9,12H,6-7H2,1-5H3/t8-,9-/m0/s1

Upstream product

• 1238951-64-8 C₁₄H₂₆N₂O₂ 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2815-34-1 2,5-dimethyl-piperazine 
• 431062-00-9 4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester 
• 431062-01-0 4-(4-fluoro-benzyl)-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester 
• 106-55-8 2,5-dimethylpiperazine 
• 1218941-14-0 C₁₈H₂₇FN₂O₂ 
• 548762-58-9 (2S,5R)-1-allyl-4-benzyloxycarbonyl-2,5-dimethylpiperazine 
• 548762-64-7 (2R,5S)-1-benzyloxycarbonyl-2,5-dimethylpiperazine 
• 155836-79-6 (+)-(2S,5R)-1-allyl-2,5-dimethylpiperazine 
• 548762-65-8 (2R,5S)-1-benzyloxycarbonyl-4-tert-butoxycarbonyl-2,5-dimethylpiperazine 

Downstream Products

• 648423-57-8 tert-butyl (2R,5S)-4-(4-cyano-3-(trifluoromethyl)phenyl)-2,5-dimethylpiperazine-1-carboxylate 
• 648423-63-6 tert-butyl (2R,5S)-4-(4-cyano-3-methoxyphenyl)-2,5-dimethylpiperazine-1-carboxylate 
• 648423-58-9 tert-butyl (2R,5S)-4-(3-chloro-4-cyanophenyl)-2,5-dimethylpiperazine-1-carboxylate 

Relevant articles and documents

HISTONE DEACETYLASE INHIBITORS

Provided herein are compounds and methods for inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3).

ARYLPIPERAZINE OPIOID RECEPTOR ANTAGONISTS

Provided are opioid receptor antagonists represented by the formula (I) where R, Y3, R1, R2, R3, R4 and R5 are as defined herein.

1-Substituted 4-(3-Hydroxyphenyl)piperazines are pure opioid receptor antagonists

This report describes the discovery that 1-substituted 4-(3-hydroxyphenyl) piperazines are pure opioid receptor antagonists. Compounds in this new series include N-phenylpropyl (3S)-3-methyl-4-(3-hydroxyphenyl)piperazine and (3R)-3-methyl-4-(3-hydroxyphenyl)piperazine, both of which display low nanomolar potencies at μ, δ, and κ receptors and pure antagonist properties in a [35S]GTPγS assay.