106-55-8

Basic information

• Product Name: Piperazine,2,5-dimethyl-
• Synonyms: 1-(2-Aminocarbonylbenzofuran-5-yl)piperazine
• CAS NO: 106-55-8
• Molecular Formula: C₆H₁₄N₂
• Molecular Weight: 288.3434
• EINECS: 203-409-4
• Mol File: 106-55-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 113-118 °C
• Boiling Point: 165.9 °C at 760 mmHg
• Flash Point: 58.3 °C
• Appearance: Gray power
• Density: 0.824 g/cm³
• Vapor Pressure: 2.25E-13mmHg at 25°C
• Refractive Index: 1.4628 (estimate)
• Storage Temp.: 2-8°C
• PKA: 9.66(at 25℃)
• CAS DataBase Reference: Piperazine,2,5-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine,2,5-dimethyl-(106-55-8)
• EPA Substance Registry System: Piperazine,2,5-dimethyl-(106-55-8)

Safety Data

• Hazard Codes: C-F
• Statements: 34-21-11
• Safety Statements: 45-36/37/39-26-16
• Hazardous Substances Data: 106-55-8(Hazardous Substances Data)

Usage

General Description

Piperazine, 2,5-dimethyl- is a chemical compound with the molecular formula C6H14N2. It is a derivative of piperazine, a heterocyclic organic compound commonly used in the pharmaceutical industry. This specific derivative contains two methyl groups attached to the second and fifth carbon atoms of the piperazine ring. 2,5-dimethyl-piperazine has been found to have potential applications in the synthesis of organic compounds and as a building block in the production of pharmaceuticals. It is also used as a solvent and intermediate in the manufacturing of various chemical products. Additionally, it may have potential use as a corrosion inhibitor and as an additive in fuel and lubricants. Overall, piperazine, 2,5-dimethyl- is a versatile chemical compound with various industrial and medicinal applications.

InChI:InChI=1/C6H10N2O4.C6H14N2/c9-5(10)3-4(6(11)12)8-2-1-7-3;1-5-3-8-6(2)4-7-5/h3-4,7-8H,1-2H2,(H,9,10)(H,11,12);5-8H,3-4H2,1-2H3

Upstream product

• 56-81-5 glycerol 
• 123-91-1 1,4-dioxane 
• 78-96-6 3-amino-2-propanol 
• 123-32-0 2,5-dimethyl-pyrazine 
• 57-55-6 propylene glycol 
• 50-70-4 D-sorbitol 
• 50-99-7 D-glucose 
• 124-38-9 carbon dioxide 
• 75-55-8 2-Methylaziridine 
• 7664-41-7 ammonia 

Downstream Products

• 123-32-0 2,5-dimethyl-pyrazine 
• 128364-93-2 2-(2,5-Dimethyl-piperazin-1-yl)-1-methyl-ethylamine 
• 128364-94-3 2-(2,5-Dimethyl-piperazin-1-yl)-propylamine 
• 132948-42-6 C₂₈H₄₂N₂O₂ 
• 132948-45-9 1-{3-[4-(3-Acetyl-6-hydroxy-5-isopropyl-2-methyl-benzyl)-2,5-dimethyl-piperazin-1-ylmethyl]-4-hydroxy-5-isopropyl-2-methyl-phenyl}-ethanone 
• 2815-34-1 2,5-dimethyl-piperazine 
• 59573-44-3 (+)-(2S,5S)-2,5-dimethylpiperazine 

Relevant articles and documents

Structure of catalytically active Rh-In bimetallic phase for amination of alcohols

The structure of Rh-In bimetallic catalysts supported on carbon for amination of alcohols was determined by XRD, TEM-EDX, XPS, CO adsorption and EXAFS. At low In/Rh ratio (In/Rh ≤ 0.2), Rh metal particles with sizes of a tetragonal RhIn alloy with a particle size of ～20 nm was formed. This tetragonal alloy has a structure with a = 0.315 nm and c = 0.328 nm where metal atoms are located at (0, 0, 0) and (0.5, 0.5, 0.5). The catalytic activity of the tetragonal RhIn alloy is much higher than that of Rh metal particles with or without indium oxide species. With an excess amount of In (In/Rh > 1) on the high Rh loading (20 wt%) catalyst, the cubic RhIn phase with a CsCl structure was observed instead of the tetragonal RhIn phase, and the catalytic activity was much decreased.

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Synthesis of 1,2-propanediamine via reductive amination of isopropanolamine over Raney Ni under the promotion of K2CO3

Catalytic amination of isopropanolamine and ammonia to 1,2-propanediamine over Raney Ni with potassium carbonate as the additive was reported. Characterization of N2 adsorption–desorption and XRD were performed to reveal the textural and structural properties of the catalysts. With the additive of potassium carbonate, the selectivity of 1,2-propanediamine was improved, while the side generation of 2,5-dimethylpiperazine was suppressed. The catalytic reaction parameters were optimized and the yield of 1,2-propanediamine reached 80% under the optimized reaction condition.

METHOD FOR PRODUCING AMINES FROM SUGAR ALCOHOLS

The present invention relates to a process for preparing amines by reacting sugar alcohols with hydrogen and an aminating agent selected from the group of ammonia and primary and secondary amines in the presence of a catalyst at a temperature of from 100° C. to 400° C. and a pressure of from 1 to 40 MPa (from 10 to 400 bar). The catalyst preferably comprises one metal or a plurality of metals or one or more oxygen compounds of the metals of groups 8 and/or 9 and/or 10 and/or 11 of the Periodic Table of the Elements. The sugar alcohol is preferably obtained by hydrogenating the corresponding sugars. The invention further relates to the use of the reaction products as an additive in cement or concrete production and in other fields of use.