19408-84-5Relevant articles and documents
Regioselective hydroxylation and dehydrogenation of capsaicin and dihydrocapsaicin by cultured cells of Phytolacca americana
Hamada, Hiroki,Ono, Tsubasa,Shimoda, Kei
, p. 103 - 107 (2022/03/18)
The biotransformations of capsaicin and dihydrocapsaicin were investigated using cultured plant cells of Phytolacca americana as biocatalysts. Four products, ie 15-hydroxycapsaicin, dihydrocapsaicin, 15-hydroxydihydrocapsaicin, and capsaicin 4-β-glucoside
Preparation method of capsaicine and capsaicine prepared by method
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Paragraph 0124-0128, (2021/04/07)
The invention provides a preparation method of capsaicine and capsaicine prepared by the method. The preparation method comprises the following steps: in the presence of an organic solvent and a catalyst, by taking vanillylamine carboxylate and carboxylic acid as reactants, carrying out amidation reaction to obtain a capsaicine reaction liquid. Compared with the prior art, the capsaicine preparation method provided by the invention at least has one of the following beneficial effects: 1) vanillylamine is converted into vanillylamine carboxylate, so that the problem of oxidative discoloration of vanillylamine is avoided, and the problems of purification, drying and storage of intermediate products are solved; 2) the vanillylamine carboxylate can be directly used for the next amidation reaction, other substances are not introduced, and the amidation reaction, operation and post-treatment are not influenced; and 3) after the vanillylamine solid is salified and dissolved, the thorough separation of the Raney Ni catalyst is facilitated, and the catalyst separated by the method can be continuously used after being treated.
Preparation method of dihydrocapsaicine and dihydrocapsaicine ester
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, (2020/06/09)
The invention relates to a preparation method of dihydrocapsaicine and dihydrocapsaicine ester. The preparation method specifically comprises the following steps: (1) condensing furfural and methyl isopropyl ketone under an alkaline condition to obtain a condensation product A; (2) carrying out ring opening on the condensation product A in water or alcohol under an acidic condition to obtain 4,7-diketo-8-methylnonanoic acid or 4,7-diketo-8-methyl nonanoate; (3) carrying out hydrodeoxygenation on 4,7-diketo-8-methylnonanoic acid or 4,7-diketo-8-methyl nonanoate, hydrogen, trifluoromethanesulfonate and a hydrogenation catalyst to obtain 8-methylnonanoic acid; and (4) reacting the 8-methylnonanoic acid with vanillamine or vanillol under the action of a catalyst to generate dihydrocapsaicine or dihydrocapsaicine ester. The method is good in atom economy, high in product yield, high in product purity, small in environmental pollution, simple in process route, convenient to operate and suitable for industrial large-scale production; the dihydrocapsaicine and the dihydrocapsaicine ester are wide in application scope and good in market prospect; raw materials are widely available and cheap; and the method is simple to operate, low in cost and suitable for industrial production.