7553-53-9

Basic information

• Product Name: Capsaicin (E/Z-Mixture)
• Synonyms: Capsaicin (E/Z-Mixture);(E/Z)-8-Methyl-N-vanillyl-6-nonenaMide;N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide
• CAS NO: 7553-53-9
• Molecular Formula: C₁₈H₂₇NO₃
• Molecular Weight: 305.41188
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 7553-53-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 60-620C
• Appearance: /
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• CAS DataBase Reference: Capsaicin (E/Z-Mixture)(CAS DataBase Reference)
• NIST Chemistry Reference: Capsaicin (E/Z-Mixture)(7553-53-9)
• EPA Substance Registry System: Capsaicin (E/Z-Mixture)(7553-53-9)

Safety Data

• Hazardous Substances Data: 7553-53-9(Hazardous Substances Data)

Usage

Chemical Properties

Capsaicin(E/Z-Mixture) is Off-White Solid

Uses

Capsaicin(E/Z-Mixture) is a representative lot is a 5:1 E:Z mixture. Has been isolated from paprika and cayenne. It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic.

Upstream product

• 1196-92-5 Vanillylamin 
• 121-33-5 vanillin 
• 61152-59-8 4-hydroxy-4-(4-hydroxy-3-methoxyphenyl)butan-2-one 
• 498-00-0 4-hydroxymethyl-2-methoxyphenol 
• 7149-10-2 vanillylamine hydrochloride 
• 2067-33-6 5-bromopentanoic acid 
• 598-23-2 3-methyl-but-1-yne 
• 1031721-21-7 (E)-{7-[bis(carboxymethyl)amino]coumarin-4-yl}methyl 2-methoxy-4-[(8-methylnon-6-enamido)methyl]phenyl carbonate 

Downstream Products

• 1031721-28-4 (E)-{7-[bis(tert-butoxycarbonylmethyl)amino]coumarin-4-yl}methyl 2-methoxy-4-[(8-methylnon-6-enamido)methyl]phenyl carbonate 
• 19408-84-5 dihydrocapsaicin 
• 1196-92-5 Vanillylamin 

Relevant articles and documents

All Non-Carbon B3NO2 Exotic Heterocycles: Synthesis, Dynamics, and Catalysis

The B3NO2 six-membered heterocycle (1,3-dioxa-5-aza-2,4,6-triborinane=DATB), comprising three different non-carbon period 2 elements, has been recently demonstrated to be a powerful catalyst for dehydrative condensation of carboxylic acids and amines. The tedious synthesis of DATB, however, has significantly diminished its utility as a catalyst, and thus the inherent chemical properties of the ring system have remained virtually unexplored. Here, a general and facile synthetic strategy that harnesses a pyrimidine-containing scaffold for the reliable installation of boron atoms is disclosed, giving rise to a series of Pym-DATBs from inexpensive materials in a modular fashion. The identification of a soluble Pym-DATB derivative allowed for the investigation of the dynamic nature of the B3NO2 ring system, revealing differential ring-closing and -opening behaviors depending on the medium. Readily accessible Pym-DATBs proved their utility as efficient catalysts for dehydrative amidation with broad substrate scope and functional-group tolerance, offering a general and practical catalytic alternative to reagent-driven amidation.

Integrated Heterogeneous Metal/Enzymatic Multiple Relay Catalysis for Eco-Friendly and Asymmetric Synthesis

Organic synthesis is in general performed using stepwise transformations where isolation and purification of key intermediates is often required prior to further reactions. Herein we disclose the concept of integrated heterogeneous metal/enzymatic multiple relay catalysis for eco-friendly and asymmetric synthesis of valuable molecules (e.g., amines and amides) in one-pot using a combination of heterogeneous metal and enzyme catalysts. Here reagents, catalysts, and different conditions can be introduced throughout the one-pot procedure involving multistep catalytic tandem operations. Several novel cocatalytic relay sequences (reductive amination/amidation, aerobic oxidation/reductive amination/amidation, reductive amination/kinetic resolution and reductive amination/dynamic kinetic resolution) were developed. They were next applied to the direct synthesis of various biologically and optically active amines or amides in one-pot from simple aldehydes, ketones, or alcohols, respectively.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF LOCAL PAIN

The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of local pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of moderate to severe pain, neuropathic pain, post herpetic neuralgia and rheumatic pains.