194151-34-3Relevant academic research and scientific papers
Nonpeptide oxytocin antagonists: Potent, orally bioavailable analogs of L-371,257 containing A 1-R-(pyridyl)ethyl ether terminus
Kuo, Michelle S.,Bock, Mark G.,Freidinger, Roger M.,Guidotti, Maribeth T.,Lis, Edward V.,Pawluczyk, Joseph M.,Perlow, Debra S.,Pettibone, Douglas J.,Quigley, Amy G.,Reiss, Duane R.,Williams, Peter D.,Woyden, Carla J.
, p. 3081 - 3086 (2007/10/03)
Structure-activity studies on the oxytocin antagonist 1 (L-371,257) have identified a new series of high affinity, receptor-selective OT antagonists in which the N-acetyl-4-piperidinyl ether terminus in 1 has been replaced with a 1-(aryl)ethoxy group.
TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS
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, (2008/06/13)
This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery. A typical compound is as follows: STR1
