19417-59-5Relevant articles and documents
FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE
-
, (2021/01/29)
This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof. This invention further provides methods for treating a disease, including but not limited to, liver disease or an abnormal liver condition; cancer (such as hepatocellular carcinoma or cholangiocarcinoma); a malignant or benign tumor of the lung, liver, gall bladder, bile duct or digestive tract; an intra- or extra-hepatic bile duct disease; a disorder of lipoprotein; a lipid-and-metabolic disorder; cirrhosis; fibrosis; a disorder of glucose metabolism; a cardiovascular or related vascular disorder; a disease resulting from steatosis, fibrosis, or cirrhosis; a disease associated with increased inflammation (such as hepatic inflammation or pulmonary inflammation); hepatocyte ballooning; a peroxisome proliferator activated receptor-associated disorder; an ATP citrate lyase disorder; an acetyl-coenzyme A carboxylase disorder; obesity; pancreatitis; or renal disease.
Selective Formation of Inter- and Intramolecular A-D-A π-π Stacking: Solid-State Structures of Bis(pyridiniopropyl)benzenes
Koizumi, Take-Aki,Tsutsui, Kanako,Tanaka, Koji
, p. 4528 - 4532 (2007/10/03)
The synthesis and molecular structures of bis(pyridiniopropyl)benzene derivatives, [1,4-(4-R-C5H4N+CH 2CH2CH2)2-C6H 4][X-2 (1, R = H, X = I; 2, R = tBu, X = Br) have been investigated. Compound 1 adopts a linear structure in the solid state and the crystal packing geometry can be defined as isolated triplets formed by the phenylene ring of one molecule and two pyridinium rings of two neighboring molecules. In contrast, compound 2 has an S-shaped arrangement, and an intramolecular acceptor-donor-acceptor triplet is formed among the central phenylene ring and two terminal pyridinium rings in the same molecule. Such a distinct difference in the crystal structures of 1 and 2 can be ascribed to the substituent on the pyridinium unit. The steric repulsion of the bulky tert-butyl group hinders intermolecular A-D-A π-π stacking. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
Synthesis and characterization of derivatized capped porhyrins
Tang, Hang,Wijesekera, Tilak P.,Dolphin, David
, p. 1366 - 1374 (2007/10/02)
The syntheses of porphyrins carrying either a fully hydrophobic cavity with a benzene moiety (32a,b) or a polar cavity with an amidobenzene (32c-d) are described.Terephthaldehyde (1) was converted to benzene-bisalkanoic acids (8, 10) and nitrobenzene-bisalkanoic acids (13 and 16) by using standard methods.The corresponding diacid chlorides 17a-d were used to acylate two equivalents of a β-unsubstituted pyrrole, and the ketonic groups were reduced by diborane.Following the transformation of the nitro function to the acetamide, appropriate modifications of the ethyl ester functions afforded the key bisformylpyrroles 25a-d.The cyanoacrylate-protected formyl pyrrole derivatives were monochlorinated at the α-methyl groups and condensed with two equivalents of an α-unsubstituted pyrrole to give the dipyrromethane dimers.Strong aqueous alkali caused saponification of the two ester groups and deprotection of the formyl functions to produce the dipyrromethane dimer 30, which, after thermal decarboxylation, was cyclized intramolecularly in acidic medium to give the porphyrins 32 (n = 4 or 5, X = H or NHCOCH3).
Synthesis and Properties of 4,4,9,9-Tetramethylparacyclophane-5,6,7,8-tetrone
Gleiter, Rolf,Kraemer, Rolf,Irngartinger, Hermann,Bissinger, Claus
, p. 252 - 258 (2007/10/02)
The synthesis of 4,4,9,9-tetramethylparacyclophane-5,6,7,8-tetrone (26) has been achieved in a multistep procedure.Compound 26 is the first cyclic tetraketone whose structure has been studied by X-ray analysis.The key intermediates were 4,4,9,9-tetramethylparacyclophane-6,7-dione (22), 6,7-bis-4,4,9,9-tetramethylparacyclophane-5,7-diene (24), and two epimeric 5,8-dihydroxy-4,4,9,9-tetramethylparacyclophane-6,7-diones 25a and 25b.X-ray analyses have been performed on 24, 25b and 26.That on 24 reveals a dihedral angle of 57 deg between the two silyenol ether groups.The product analyses and the configurations of 25a and 25b together with the isolation of the bis(epoxide) intermediate 28 allow conclusions to be drawn on the oxidation mechanism of 24 with m-CPBA (Rubottom reaction).The stability of 26 is ascribed to steric factors.
