70364-29-3

Usage

General Description

3-[4-(2-ethoxycarbonyl-ethyl)-phenyl]-propionic acid ethyl ester is a chemical compound belonging to the class of propionic acid derivatives. It is a synthetic organic compound with the molecular formula C19H22O4. This chemical is commonly used as a non-steroidal anti-inflammatory drug (NSAID) and is known for its analgesic and anti-inflammatory properties. It acts by inhibiting the production of prostaglandins, thereby reducing pain and inflammation in the body. 3-[4-(2-ETHOXYCARBONYL-ETHYL)-PHENYL]-PROPIONIC ACID ETHYL ESTER is often used in the pharmaceutical industry for the formulation of pain relief medications and has potential therapeutic applications in the management of various inflammatory conditions.

Upstream product

• 4251-21-2 3,3'-(1,4-phenylene)dipropanoic acid 
• 141-97-9 ethyl acetoacetate 
• 623-25-6 p-Xylylene dichloride 
• 64-17-5 ethanol 
• 106-37-6 1.4-dibromobenzene 
• 140-88-5 ethyl acrylate 
• 3054-95-3 acrylaldehyde diethyl acetal 
• 624-38-4 para-diiodobenzene 
• 23713-85-1 1,4-phenylenediacrylic acid 
• 623-27-8 terephthalaldehyde, 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 17088-28-7 ethyl 3-(4-(2-ethoxycarbonylvinyl)phenyl)propenoate 
• 16323-43-6 1,4-phenylenediacrylic acid 
• 23746-57-8 diethyl (2E,2′E)-3,3′-benzene-1,4-diylbis-prop-2-enoate 

Downstream Products

• 4251-21-2 3,3'-(1,4-phenylene)dipropanoic acid 
• 19417-58-4 [1,4-phenylene]-bis(3-hydroxypropane) 
• 107399-42-8 3,3'-(1,4-phenylene)dipropanal 
• 1404469-43-7 C₁₂H₁₈N₄O₂ 
• 46744-67-6 Diacyl chloride of benzene-1,4-dipropionic acid 
• 1239517-47-5 3,3'-(1,4-phenylene)bis(propane-3,1-diyl)bis(4-methylbenzenesulfonate) 
• 144582-39-8 C₆₀H₇₅N₇O₉ 
• 144582-38-7 C₅₈H₇₁N₇O₉ 
• 144582-37-6 C₅₈H₇₂N₆O₈ 
• 144582-06-9 1,4-Bis<4-<2-((5-ethoxycarbonyl-3-ethyl-4-methylpyrrol-2-yl)methyl)-5-(2-cyano-2-methoxycarbonylvinyl)-4-methylpyrrol-3-yl>butyl>benzene 
• 144582-42-3 C₄₈H₆₁N₅O₇ 
• 144582-41-2 C₄₆H₅₇N₅O₇ 
• 144582-40-1 C₄₆H₅₈N₄O₆ 
• 144582-07-0 1,4-Bis<4-<2-((5-carboxy-3-ethyl-4-methylpyrrol-2-yl)methyl)-5-formyl-4-methylpyrrol-3-yl>butyl>benzene 

Relevant academic research and scientific papers

One-Pot, Tandem Wittig Hydrogenation: Formal C(sp3)-C(sp3) Bond Formation with Extensive Scope

A one-pot, tandem Wittig hydrogenation of aldehydes with stabilized ylides is reported, representing a formal C(sp3)-C(sp3) bond construction. The tandem reaction operates under mild conditions, is high yielding, and is broad in scope. Chemoselectivity for olefin reduction is observed, and the methodology is demonstrated in the synthesis of lapatinib analogues and a formal synthesis of (±)-cuspareine. Early insights suggest that the chemoselectivity observed in the reduction step is due to partial poisoning of the catalyst, after step one, thus adding to the power of the one-pot procedure.

The Cooperative Effect of Both Molecular and Supramolecular Chirality on Cell Adhesion

Although helical nanofibrous structures have great influence on cell adhesion, the role played by chiral molecules in these structures on cells behavior has usually been ignored. The chirality of helical nanofibers is inverted by the odd–even effect of methylene units from homochiral l-phenylalanine derivative during assembly. An increase in cell adhesion on left-handed nanofibers and weak influence of cell behaviors on right-handed nanofibers are observed, even though both were derived from l-phenylalanine derivatives. Weak and negative influences on cell behavior was also observed for left- and right-handed nanofibers derived from d-phenylalanine, respectively. The effect on cell adhesion of single chiral molecules and helical nanofibers may be mutually offset.

EMM-28, A NOVEL SYNTHETIC CRYSTALLINE MATERIAL, ITS PREPARATION AND USE

A novel synthetic crystalline material, EMM-28, can be synthesized in the presence of an organic structure directing agent (Q) selected from one or more of the following dications: EMM-28 may be used in organic compound conversion reactions and sorptive processes.

Chemoselective Heck arylation of acrolein diethyl acetal catalyzed by an oxime-derived palladacycle

A dimeric 4-hydroxyacetophenone oxime-derived palladacycle has been used as a very efficient precatalyst for the chemoselective arylation of acrolein diethyl acetal to give either cinnamaldehyde derivatives or 3-arylpropanoate esters by proper choice of the reaction conditions. The synthesis of cinnamaldehyde derivatives can be performed by Heck reaction of acrolein diethyl acetal with iodo-, bromo- or chloroarenes in N,N-dimethylacetamide (DMA) using K2CO3 as base at 120°C and tetra-n-butylammonium acetate (TBAA) and KCl as additives, followed by acid workup. In the case of 3-arylpropanoate esters the corresponding arylation of acrolein diethyl acetal with iodoarenes can be performed at 90°C in aqueous DMA using (dicylohexyl)methylamine as base, whereas for bromoarenes the reaction has to be performed at 120°C using tetra-n-butylammonium bromide (TBAB) as additive. Alternatively, this process can be performed under microwave irradiation. These couplings take place in good yields and with lower catalyst loading than with palladium(II) acetate as well as in shorter reaction times and with lower excess of acrolein diethyl acetal.

3-arylpropanoate esters through the palladium-catalyzed reaction of aryl halides with acrolein diethyl acetal

The reaction of aryl halides with acrolein diethyl acetal in the presence of Pd(OAc)2, n-Bu3N, and n-Bu4NCl in DMF at 90°C affords ethyl 3-arylpropanoates. A variety of functional groups are tolerated in the aryl halides, including ether, aldehyde, ketone, ester, nitrile, and nitro groups. ortho-Substituents do not hamper the reaction. 3-Arylpropanoate esters were isolated in good to excellent yields with many neutral, electron-rich and electron-poor aryl iodides and electron-poor aryl bromide. Neutral and electron-rich aryl bromides gave the desired ester in moderate yields.

Selective Formation of Inter- and Intramolecular A-D-A π-π Stacking: Solid-State Structures of Bis(pyridiniopropyl)benzenes

The synthesis and molecular structures of bis(pyridiniopropyl)benzene derivatives, [1,4-(4-R-C5H4N+CH 2CH2CH2)2-C6H 4][X-2 (1, R = H, X = I; 2, R = tBu, X = Br) have been investigated. Compound 1 adopts a linear structure in the solid state and the crystal packing geometry can be defined as isolated triplets formed by the phenylene ring of one molecule and two pyridinium rings of two neighboring molecules. In contrast, compound 2 has an S-shaped arrangement, and an intramolecular acceptor-donor-acceptor triplet is formed among the central phenylene ring and two terminal pyridinium rings in the same molecule. Such a distinct difference in the crystal structures of 1 and 2 can be ascribed to the substituent on the pyridinium unit. The steric repulsion of the bulky tert-butyl group hinders intermolecular A-D-A π-π stacking. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Linked cyclic polyamines with activity against hiv.

There is disclosed a pharmaceutical composition comprising as active ingredient a linked cyclic compound of general formula I,Z - R - A - R' - Y in which Z and Y are independently cyclic polyamine moieties having from 9 to 32 ring members and from 3 to 8 amine nitrogens in the ring spaced by 2 or more carbon atoms from each other, ???A is an aromatic or heteroaromatic moiety, ???R and R' are each a substituted or unsubstituted alkylene chain or heteroatom containing chain. or an acid addition salt or metal complex thereof, in admixture or association with a pharmaceutically acceptable diluent or carrier.

Nickel-catalyzed electrochemical arylation of activated olefins

Nickel-catalyzed electrochemical conjugate additions of substituted aryl bromides to activated olefins under recently optimized reaction conditions are reported. Good to high yields were obtained, whatever the nature of substituents in the meta- and para-positions of the benzene ring. In the ortho-substituted series, yields were good with electron-donating substituents, but low with electron-withdrawing groups. The activation of aryl chlorides and the sequential functionalization of aryl dihalides were also investigated.

Synthesis and characterization of derivatized capped porhyrins

The syntheses of porphyrins carrying either a fully hydrophobic cavity with a benzene moiety (32a,b) or a polar cavity with an amidobenzene (32c-d) are described.Terephthaldehyde (1) was converted to benzene-bisalkanoic acids (8, 10) and nitrobenzene-bisalkanoic acids (13 and 16) by using standard methods.The corresponding diacid chlorides 17a-d were used to acylate two equivalents of a β-unsubstituted pyrrole, and the ketonic groups were reduced by diborane.Following the transformation of the nitro function to the acetamide, appropriate modifications of the ethyl ester functions afforded the key bisformylpyrroles 25a-d.The cyanoacrylate-protected formyl pyrrole derivatives were monochlorinated at the α-methyl groups and condensed with two equivalents of an α-unsubstituted pyrrole to give the dipyrromethane dimers.Strong aqueous alkali caused saponification of the two ester groups and deprotection of the formyl functions to produce the dipyrromethane dimer 30, which, after thermal decarboxylation, was cyclized intramolecularly in acidic medium to give the porphyrins 32 (n = 4 or 5, X = H or NHCOCH3).