1942-82-1

Basic information

• Product Name: Phosphine oxide, [1,1'-biphenyl]-2-yldiphenyl-
• CAS NO: 1942-82-1
• Molecular Formula: C24H19OP
• Molecular Weight: 354.388
• Mol File: 1942-82-1.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Phosphine oxide, [1,1'-biphenyl]-2-yldiphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphine oxide, [1,1'-biphenyl]-2-yldiphenyl-(1942-82-1)
• EPA Substance Registry System: Phosphine oxide, [1,1'-biphenyl]-2-yldiphenyl-(1942-82-1)

Safety Data

• Hazardous Substances Data: 1942-82-1(Hazardous Substances Data)

Upstream product

• 2113-51-1 2-iodobiphenyl 
• 4559-70-0 Diphenylphosphine oxide 
• 321-60-8 2-fluorobiphenyl 
• 1806-29-7 2,2'-dihydroxybiphenyl 
• 90-43-7 2-Phenylphenol 
• 17763-65-4 biphenyl-2-yl trifluoromethanesulfonate 
• 90-41-5 2-phenylaniline 
• 100-58-3 phenylmagnesium bromide 
• 947-84-2 2-Biphenylcarboxylic acid 
• 16664-52-1 hex-5-en-1-yn-1-ylbenzene 
• 1079-66-9 chloro-diphenylphosphine 
• 2052-07-5 2-Bromobiphenyl 
• 98-80-6 phenylboronic acid 
• 791-28-6 Triphenylphosphine oxide 

Downstream Products

• 843615-09-8 (2'-hydroxy-[1,1'-biphenyl]-2-yl)diphenylphosphine oxide 
• 1031-13-6 5-phenyl-5H-dibenzophosphole-5-oxide 

Relevant articles and documents

Phosphinylation of Non-activated Aryl Fluorides through Nucleophilic Aromatic Substitution at the Boundary of Concerted and Stepwise Mechanisms

Non-activated aryl fluorides reacted with potassium diorganophosphinites through a nucleophilic aromatic substitution (SNAr) reaction. Remarkably, both electron-neutral and electron-rich aryl fluorides participated in the reaction with substantially stabilized anionic P nucleophiles to form the corresponding tertiary phosphine oxides. Quantum chemical calculations suggested a nucleophile-dependent mechanism that involves both concerted and stepwise SNAr reaction pathways.

Homogeneous Palladium-Catalyzed Selective Reduction of 2,2′-Biphenols Using HCO 2H as Hydrogen Source

An efficient homogeneous palladium-catalyzed selective deoxygenation of 2,2′-biphenols by reduction of aryl triflates with HCO 2H as the hydrogen source is reported. This protocol complements the current method based on heterogeneous Pd/C-catalyzed hydrogenation with hydrogen gas. This process provided the reduction products in good to excellent yields, which could be readily converted to various synthetically useful molecules, especially ligands for catalytic synthesis.

Palladium-Catalyzed Direct Decarbonylative Phosphorylation of Benzoic Acids with P(O)–H Compounds

A direct decarbonylative phosphorylation of benzoic acids catalyzed by palladium was disclosed. Under the reaction conditions, a wide range of benzoic acids coupled readily with all the three kinds of P(O)–H compounds, i.e. secondary phosphine oxides, H-phosphinates and H-phosphonates, producing the corresponding organophosphorus compounds in good to high yields. This reaction could be conducted at a gram scale and applied in the late-stage phosphorylative modification of carboxylic acids drug molecules. These results well demonstrated the potential synthetic value of this new reaction in organic synthesis.