194221-59-5Relevant academic research and scientific papers
Photolabile linker for the solid-phase synthesis of base-sensitive oligonucleotides
Dell'Aquila, Christelle,Imbach, Jean-Louis,Rayner, Bernard
, p. 5289 - 5292 (1997)
o-Nitrophenyl-1,3-propanediol was covalently linked to long chain alkyl amine controlled pore glass (LCAA-CPG) beads through a stable phosphoramidate diester link. The resulting solid support was found suitable for the automated synthesis of 3'-phosphate unmodified as well as base-sensitive oligonucleotides. Efficient cleavage from the solid support was achieved by photolysis.
