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19430-83-2

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19430-83-2 Usage

General Description

3,4'-Diaminodiphenylmethane, also known as Methylene dianiline or MDA, is a chemical compound extensively used in the production of several polyurethane foams, epoxy resins, spandex fibers, and in other industrial manufacturing procedures. It features two primary amine groups linked by a central benzene-derived moiety. Exposure to MDA, which appears as a light yellow to dark brown solid or crystal, can lead to several health hazards due to its high toxicity, making it a potential occupational carcinogen. It may cause skin and eye irritation, liver and kidney damage, and mutagenic effects. For this reason, safety measures should be applied when handling this compound.

Check Digit Verification of cas no

The CAS Registry Mumber 19430-83-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,4,3 and 0 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 19430-83:
(7*1)+(6*9)+(5*4)+(4*3)+(3*0)+(2*8)+(1*3)=112
112 % 10 = 2
So 19430-83-2 is a valid CAS Registry Number.

19430-83-2 Well-known Company Product Price

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  • TCI America

  • (D1684)  3,4'-Diaminodiphenylmethane  >98.0%(GC)(T)

  • 19430-83-2

  • 1g

  • 550.00CNY

  • Detail
  • TCI America

  • (D1684)  3,4'-Diaminodiphenylmethane  >98.0%(GC)(T)

  • 19430-83-2

  • 5g

  • 1,450.00CNY

  • Detail
  • TCI America

  • (D1684)  3,4'-Diaminodiphenylmethane  >98.0%(GC)(T)

  • 19430-83-2

  • 25g

  • 3,990.00CNY

  • Detail
  • Aldrich

  • (655449)  3,4′-Diaminodiphenylmethane  95%

  • 19430-83-2

  • 655449-1G

  • 882.18CNY

  • Detail

19430-83-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-[(4-aminophenyl)methyl]aniline

1.2 Other means of identification

Product number -
Other names 3,4'-DiaMinodiphenylMethane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19430-83-2 SDS

19430-83-2Relevant articles and documents

Guanidinium-based derivatives: Searching for new kinase inhibitors

Diez-Cecilia, Elena,Kelly, Brendan,Perez, Concepcion,Zisterer, Daniela M.,Nevin, Daniel K.,Lloyd, David G.,Rozas, Isabel

, p. 427 - 441 (2014/06/09)

Considering the structural similarities between the kinase inhibitor sorafenib and 4,4′-bis-guanidinium derivatives previously prepared by Rozas and co., which display interesting cytotoxicity in cancer cells, we have studied whether this activity could result from kinase inhibition. Five new families have been prepared consisting of unsubstituted and aryl-substituted 3,4′-bis-guanidiniums, 3,4′-bis-2-aminoimidazolinium and 3-acetamide-4′-(4-chloro-3-trifluoromethylphenyl)guanidinium derivatives. Cytotoxicity (measuring the IC50 values) and apoptosis studies in human HL-60 promyelocytic leukemia cells were carried out for these compounds. Additionally, their potential inhibitory effect was explored on a panel of kinases known to be involved in apoptotic pathways. The previously prepared cytotoxic 4,4′-bis-guanidiniums did not inhibit any of these kinases; however, some of the novel 3,4′-substituted derivatives showed a high percentage inhibition of RAF-1/MEK-1, for which the potential mode of binding was evaluated by docking studies. The interesting antitumour properties showed by these compounds open up new exciting lines of investigation for kinase inhibitors as anticancer agents and also highlights the relevance of the guanidinium moiety for protein kinase inhibitors chemical design.

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