194367-88-9Relevant academic research and scientific papers
Synthesis of 2H-1-benzopyrans via palladacycles with a metal-bonded stereogenic carbon
Portscheller, Janelle L.,Malinakova, Helena C.
, p. 3679 - 3681 (2002)
(graph presented) Stable oxapalladacycles have been prepared and converted into a series of highly functionalized 2H-1-benzopyrans via regioselective insertion of activated alkynes.
RENIN INHIBITORS
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Page/Page column 27, (2009/04/25)
The present invention relates to biphenyl compounds of formula (I). These compounds are renin inhibitors of a non- peptidic nature and of low molecular weight. The invention further relates to a pharmaceutical composition containing said compounds, as wel
CYCLIC INDOLE-3-CARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
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Page/Page column 82, (2009/09/05)
The present invention relates to cyclic indole-3-carboxamides of the Formula (I), wherein A, R, R10, R20, R30, R40, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the Formula (I), their use and pharmaceutical compositions comprising them.
Enantioselective catalysis 107: new optically active deltacyclenes as building blocks for the synthesis of expanded phosphanes
Brunner, Henri,Reimer, Alfred
, p. 307 - 314 (2007/10/03)
The cobalt-catalyzed homo Diels-Alder reaction of norbornadiene and terminal acetylenes yields chiral deltacyclenes.We tried to extend the scope of this reaction to acetylenes containing a heteroatom (i) in the propargylic position, (ii) in the ortho position of phenylacetylene or (iii) directly bonded to the triple bond.The synthesis of nine new substituted deltacyclenes with cobalt cytalysts derived from CoI2 and zinc powder or Co(acac)3 and Et2AlCl is described.Using Norphos as a cocatalyst, the products are obtained in high enantiomeric excess. - Keywords: enantioselective homogeneous catalysis; homo Diels-Alder reaction; deltacyclene; terminal acetylene
