19457-57-9

Basic information

• Product Name: 6-methylene-4-pregnene-3,20-dione
• Synonyms: 6-methylene-4-pregnene-3,20-dione
• CAS NO: 19457-57-9
• Molecular Formula: C22H30 O2
• Molecular Weight: 0
• Mol File: 19457-57-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 465.7°Cat760mmHg
• Flash Point: 173.2°C
• Appearance: /
• Density: 1.08g/cm³
• Vapor Pressure: 7.53E-09mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: 6-methylene-4-pregnene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methylene-4-pregnene-3,20-dione(19457-57-9)
• EPA Substance Registry System: 6-methylene-4-pregnene-3,20-dione(19457-57-9)

Safety Data

• Hazardous Substances Data: 19457-57-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C22H30O2/c1-13-11-16-18-6-5-17(14(2)23)21(18,3)10-8-19(16)22(4)9-7-15(24)12-20(13)22/h12,16-19H,1,5-11H2,2-4H3/t16-,17+,18-,19-,21+,22+/m0/s1

Upstream product

• 805-33-4 3-pyrrolidino-pregna-3,5-dien-20-one 
• 903-03-7 3-hydroxypregna-3,5-diene-20-one-3-methyl ether 
• 25581-83-3 1-((8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-trimethylsilanyloxy-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethanone 
• 57-83-0 Progesterone 
• 79694-57-8 20β-Acetoxy-6-methylene-4-pregnen-3-one 
• 51086-70-5 6β-Hydroxymethyl-pregn-4-en-3,20-dion 
• 79694-58-9 20β-Hydroxy-6-methylene-4-pregnen-3-one 
• 74601-18-6 (8S,9S,10R,13S,14S,17S)-17-Acetyl-6-dimethylaminomethyl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 109-87-5 Dimethoxymethane 

Relevant articles and documents

REGIOSELECTIVE MANNICH REACTIONS VIA TRIMETHYLSILYL ENOL ETHERS

Site-specific reactions of trimethylsilyl enolates and trimethylsilyldienolates are described.

PROSTATIC CANCER. I. 6-METHYLENE-4-PREGNEN-3-ONES AS IRREVERSIBLE INHIBITORS OF RAT PROSTATIC Δ4-3-KETOSTEROID 5α-REDUCTASE

Some derivatives of 6-methylene-4-pregnen-3-one were studied as inhibitors of Δ4-3-ketosteroid 5α-reductase.Maximum inhibitory activity was shown by 17-acetoxy-6-methylene-4-pregnene-3,20-dione (AMPD).Irreversible inactivation was observed following preincubation of the enzyme with NADPH and AMPD.This inactivation was found to occur only in the presence of NADPH.As such enzyme inactivation was not due to the formation of a more inhibitory metabolic product, or to the formation of superoxide via a cytochrome P-450/NADPH pathway, it seemed likely that the observed inactivation was derived from an irreversible combination of the enzyme with AMPD.That this was probably the case was established by kinetic studies which revealed a pattern compatible with a kcat type of mechanism.