194599-07-0Relevant articles and documents
Optimization of pyrrolidinone based HIV protease inhibitors
Sherrill, Ronald G.,Andrews, C. Webster,Bock, William J.,Davis-Ward, Ronda G.,Furfine, Eric S.,Hazen, Richard J.,Rutkowske, Randy D.,Spaltenstein, Andrew,Wright, Lois L.
, p. 81 - 84 (2007/10/03)
The synthesis and enhanced antiviral activity of a series of P1′-optimized 3,5-dibenzyl pyrrolidinone based HIV protease inhibitors is described. Optimization of P1-substituted pyrrolidinone based HIV protease inhibitors has yielded analogs with very pote