194606-27-4

Upstream product

• 108-05-4 vinyl acetate 
• 36039-36-8 2-(4-isobutylphenyl)propan-1-ol 
• 538-93-2 1-phenyl-2-methylpropane 
• 194606-12-7 2-tert-butyl-4,5-dihydro-5-(4-isobutylphenyl)-1,3-dioxepin 
• 194606-19-4 (2R)-(+)-3-acetoxy-2-(4-isobutylphenyl)-1-propanol 
• 194606-15-0 2-(4-isobutylphenyl)-1,3-propanediol 
• 85609-09-2 1-iodo-4-isobutylbenzene 
• 194606-25-2 Acetic acid (S)-2-(4-isobutyl-phenyl)-3-(toluene-4-sulfonyloxy)-propyl ester 

Downstream Products

• 51146-56-6 (S)-ibuprofen 
• 114937-30-3 (2S)-2-<4-(2-Methylpropyl)phenyl>propan-1-ol 

Relevant academic research and scientific papers

Lipase-mediated asymmetric construction of 2-arylpropionic acids: Enantiocontrolled syntheses of S-naproxen and S-ibuprofen

A general and enantiocontrolled synthetic route to 2-arylpropionic acids, represented by non-steroidal anti-inflammatory drugs S-naproxen 1a and S-ibuprofen 1b, has been developed by employing the lipase-mediated asymmetric acetylation of prochiral 2-aryl-1,3-propanediol 3, which has been derived via a Heck reaction, as the key step.

DIFFERENCES IN REACTIVITY AND ENANTIOSELECTIVITY IN LIPASE REACTIONS WITH CARBOXYLIC ESTERS AND ALCOHOLS BEARING THE SAME STEREOGENIC CENTER

The reaction rate and stereochemical outcome of lipase reactions obtained with carboxylic esters and alcohols, which contain the same stereogenic center, can be modulated by changing the mode of the lipase reaction, i.e. ester hydrolysis versus alcohol acetylation.