194738-01-7Relevant academic research and scientific papers
The synthesis and evaluation of the major metabolites of mazapertine
Reitz, Allen B.,McDonnell, Mark E.,Baxter, Ellen W.,Codd, Ellen E.,Wu, Wu-Nan
, p. 1927 - 1930 (2007/10/03)
Several of the key metabolites of mazapertine, a novel antipsychotic agent, were prepared in order to firmly establish their chemical structure and to obtain samples for biological testing. Hydroxymazapertine 3 was synthesized via a multi-step procedure starting from 5-fluoro-2-nitrophenol (8). Alcohol 4 was originally proposed for one of the major metabolites, but the confirmed structure after synthesis was isomer 20.
