194792-58-0

Upstream product

• 25345-77-1 2-(2-propenyl)-4-phenoxyphenol 
• 108-95-2 phenol 
• 459-57-4 4-fluorobenzaldehyde 
• 831-82-3 4-Phenoxyphenol 
• 67-36-7 4-phenoxy benzaldehyde 
• 25345-76-0 1-phenoxy-4-allyloxybenzene 

Downstream Products

• 1026360-23-5 {5-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy]-indan-1-yl}-acetic acid ethyl ester 
• 314752-63-1 4-(4-bromobutoxy)-3-propylphenyl phenyl ether 
• 228577-59-1 methyl 4-(3-(2-propyl-4-phenoxy-phenoxy)-propoxy)phenylacetate 
• 228579-10-0 4-(3-bromopropoxy)-3-propylphenyl phenyl ether 
• 656233-17-9 2-imino-5-{4-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy]-3-propyl-phenyl}-thiazolidin-4-one 
• 656233-08-8 5-{3-chloro-4-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy]-phenyl}-2-imino-thiazolidin-4-one 
• 656233-07-7 5-{3-fluoro-4-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy]-phenyl}-2-imino-thiazolidin-4-one 
• 656233-15-7 2-imino-5-{3-methoxy-4-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy]-phenyl}-thiazolidin-4-one 
• 656233-13-5 2-imino-5-{3-methyl-4-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy]-phenyl}-thiazolidin-4-one 
• 656233-02-2 2-imino-5-{4-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy]-phenyl}-thiazolidin-4-one 

Relevant academic research and scientific papers

Indanylacetic acid derivatives carrying 4-thiazolyl-phenoxy tail groups, a new class of potent PPAR α/γ/δ pan agonists: Synthesis, structure-activity relationship, and in vivo efficacy

Compounds that simultaneously activate the three peroxisome proliferator-activated receptor (PPAR) subtypes alpha, gamma, and delta hold potential to address the adverse metabolic and cardiovascular conditions associated with diabetes and the metabolic sy

5-Aryl thiazolidine-2,4-diones: Discovery of PPAR dual α/γ agonists as antidiabetic agents

A novel series of 5-aryl thiazolidine-2,4-diones based dual PPARα/γ agonists was identified. A number of highly potent and orally bioavailable analogues were synthesized. Efficacy study results of some of these analogues in the db/db mice model of type 2 diabetes showed them superior to rosiglitazone in correcting hyperglycemia and hypertriglyceridemia.

Antidiabetic agents

The instant invention is concerned with aryl and heteroaryl oxyacetic acid type compounds which are useful antidiabetic compounds. Compositions and methods for the use of the compounds in the treatment of diabetes and related diseases and for lowering triglyceride levels are also disclosed.