19481-81-3

Basic information

• Product Name: Benzeneacetonitrile, a-chloro-a-phenyl-
• CAS NO: 19481-81-3
• Molecular Formula: C14H10ClN
• Molecular Weight: 227.693
• Mol File: 19481-81-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, a-chloro-a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, a-chloro-a-phenyl-(19481-81-3)
• EPA Substance Registry System: Benzeneacetonitrile, a-chloro-a-phenyl-(19481-81-3)

Safety Data

• Hazardous Substances Data: 19481-81-3(Hazardous Substances Data)

Upstream product

• 4695-13-0 2,2-diphenylacetamide 
• 86-29-3 Diphenylacetonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 2051-90-3 Dichlorodiphenylmethane 
• 119-61-9 benzophenone 
• 101095-43-6 chloro-diphenyl-acetic acid-(trichlorophosphoranyliden-amide) 

Downstream Products

• 92874-48-1 (2-chloro-ethoxy)-diphenyl-acetonitrile 
• 3122-21-2 2,2,3,3-tetraphenylsuccinonitrile 
• 98888-99-4 2(1-Hexahydroazepino)-2,2-diphenylacetonitril 
• 6639-43-6 2,2,2-triphenylacetonitrile 
• 30592-53-1 imidazol-1-yl-diphenyl-acetonitrile 
• 83695-02-7 α,α-diphenyl-1H-(5-methylimidazole)-1-acetonitrile 
• 83695-01-6 α,α-diphenyl-1H-(4-methylimidazole)-1-acetonitrile 
• 4336-65-6 C₃₂H₂₇NOP⁽¹⁺⁾*Cl^(1-) 
• 7473-97-4 1,1-diphenyl-1-methoxy-propan-2-one 
• 15427-66-4 2,2-Diphenyl-2-pyrrolidinoacetamid 
• 98889-00-0 2-(1-Hexahydroazepino)-2,2-diphenylacetamid 
• 15427-70-0 2<4-(1,4-Oxazino)>-2,2-diphenylacetamid 
• 4336-66-7 C₃₂H₂₆NOP 
• 4336-63-4 diethyl (2,2-diphenylvinylidene)phosphoramidate 

Relevant articles and documents

Titanium(IV) Chloride Catalyzed Cyanation of Benzylic Halides With Trimethylsilyl Cyanide

Six sterically hindered benzylic chlorides have been substituted with cyano groups in excellent yields with trimethylsilyl cyanide and titanium tetrachloride in methylene chloride.Both monochloro substrates such as diphenylmethyl chloride and triphenylmethyl chloride and dichloro substrates such as dichlorodiphenylmethane and sym-tetraphenylethylene dichloride were studied.Because isonitriles are plausible reaction intermediates, the isomerization of trityl isonitrile by TiCl4 and by trityl tetrafluoroborate was studied at 0 and -78 deg C.Both reagents catalyze conversion to triphenylacetonitrile at 0 deg C while only trityl tetrafluoroborate is effective at -78 deg C.It was also found that trityl tetrafluoroborate reacts with trimethylsilyl cyanide in the absence of TiCl4 to give triphenylacetonitrile in 96percent yield.

ONE-POT SYNTHESIS OF α-CHLORONITRILES FROM ARYLCARBONYL COMPOUNDS

α-Chloronitriles are prepared by the reaction of arylcarbonyl compounds and trimethylsilyl cyanide with a stoichiometric amount of titanium tetrachloride in good yields.