19514-02-4

Basic information

• Product Name: Ethanone, 2-(3-methylphenoxy)-1-phenyl-
• CAS NO: 19514-02-4
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Mol File: 19514-02-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(3-methylphenoxy)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(3-methylphenoxy)-1-phenyl-(19514-02-4)
• EPA Substance Registry System: Ethanone, 2-(3-methylphenoxy)-1-phenyl-(19514-02-4)

Safety Data

• Hazardous Substances Data: 19514-02-4(Hazardous Substances Data)

Upstream product

• 108-39-4 3-methyl-phenol 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 
• 532-27-4 1-chloroacetophenone 

Downstream Products

• 63188-58-9 2-bromo-4-methyl-3-phenylbenzofuran 
• 63188-59-0 2-bromo-6-methyl-3-phenyl-benzofuran 
• 50781-28-7 2-oxo-2-phenyl-ethyl 
• 41115-75-7 3-Methylphenoxyl radical 
• 34403-03-7 1-phenyl-2-(meta-tolyl)ethanone 
• 108-39-4 3-methyl-phenol 
• 98-86-2 acetophenone 
• 495-71-6 phenacylacetophenone 
• 63188-57-8 6-methyl-3-phenylbenzofuran 
• 33008-48-9 6-Methyl-2-phenylbenzofuran 
• 63188-56-7 4-methyl-3-phenylbenzofuran 

Relevant articles and documents

Synthesis of aromatic ethers without organic solvent and inorganic carrier under microwave irradiation

A simple, rapid and efficient procedure for the synthesis of aromatic ethers via microwave irradiation without any organic solvent and inorganic carrier is reported.

Synthesis of benzofurans from the cyclodehydration of α-phenoxy ketones mediated by Eaton’s reagent

Cyclodehydration of α-phenoxy ketones promoted by Eaton’s reagent (phosphorus pentoxide–methanesulfonic acid) is used to prepare 3-substituted or 2,3-disubstituted benzofurans with moderate to excellent yields under mild conditions. The method provides a facile access to benzofurans from readily available starting materials such as phenols and α-bromo ketones. The reaction is highly efficient, which is attributed to the good reactivity and fluidity of Eaton’s reagent. The reaction can be applied to prepare naphthofurans, furanocoumarins, benzothiophenes, and benzopyrans.

Liquid chromatographic resolution of mexiletine and its analogs on crown ether-based chiral stationary phases

Mexiletine, an effective class IB antiarrhythmic agent, and its analogs were resolved on three different crown ether-based chiral stationary phases (CSPs), one (CSP 1) of which is based on (+)-(18-crown-6)-2,3,11,12- tetracarboxylic acid and the other two (CSP 2 and CSP 3) are based on (3,3'-diphenyl-1,1'-binaphthyl)-20-crown-6. Mexiletine was resolved with a resolution (RS) of greater than 1.00 on CSP 1 and CSP 3 containing residual silanol group-protecting n-octyl groups on the silica surface, but with a resolution (RS) of less than 1.00 on CSP 2. The chromatographic behaviors for the resolution of mexiletine analogs containing a substituted phenyl group at the chiral center on the three CSPs were quite dependent on the phenoxy group of analytes. Namely, mexiletine analogs containing 2,6-dimethylphenoxy, 3,4-dimethylphenoxy, 3-methylphenoxy, 4-methylphenoxy, and a simple phenoxy group were resolved very well on the three CSPs even though the chiral recognition efficiencies vary with the CSPs. However, mexiletine analogs containing 2-methylphenoxy group were not resolved at all or only slightly resolved. Among the three CSPs, CSP 3 was found to show the highest chiral recognition efficiencies for the resolution of mexiletine and its analogs, especially in terms of resolution (RS). Chirality 26:272-278, 2014. 2014 Wiley Periodicals, Inc.