34403-03-7

Basic information

• Product Name: 2-(3-METHYLPHENYL)ACETOPHENONE
• Synonyms: 2-(3-METHYLPHENYL)ACETOPHENONE
• CAS NO: 34403-03-7
• Molecular Formula: C₁₅H₁₄O
• Molecular Weight: 210.27
• Mol File: 34403-03-7.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 337.3°C at 760 mmHg
• Flash Point: 144.7°C
• Appearance: /
• Density: 1.062g/cm³
• Vapor Pressure: 0.000106mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 2-(3-METHYLPHENYL)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-METHYLPHENYL)ACETOPHENONE(34403-03-7)
• EPA Substance Registry System: 2-(3-METHYLPHENYL)ACETOPHENONE(34403-03-7)

Safety Data

• Hazardous Substances Data: 34403-03-7(Hazardous Substances Data)

Usage

Type of Compound

Ketone

Usage

Flavoring agent, fragrance, pharmaceutical production, organic synthesis intermediate

Aroma

Sweet, floral

Physical State

Colorless to pale yellow liquid

Melting Point

23-24°C

Boiling Point

275-276°C

Potential Applications

Antioxidant, materials science

InChI:InChI=1/C15H14O/c1-12-6-5-7-13(10-12)11-15(16)14-8-3-2-4-9-14/h2-10H,11H2,1H3

Upstream product

• 620-13-3 1-bromomethyl-3-methyl-benzene 
• 624-31-7 4-tolyl iodide 
• 98-86-2 acetophenone 
• 98-88-4 benzoyl chloride 
• 71-43-2 benzene 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 197245-87-7 (2,4,6-trimethylphenyl)(3’-methylphenyl)iodonium triflate 
• 108-67-8 1,3,5-trimethyl-benzene 
• 16717-64-9 1-azidostyrene 
• 536-89-0 m-tolylhydrazine 
• 93-58-3 benzoic acid methyl ester 
• 108-38-3 m-xylene 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 591-17-3 meta-bromotoluene 

Downstream Products

• 19419-02-4 8-methyl-3-phenylcinnoline 
• 10501-72-1 6-methyl-3-phenylcinnoline 
• 40103-79-5 1-(3-methylphenyl)-2-phenyl-1,2-ethanedione 
• 1283117-19-0 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-phenyl-5-m-tolyl-3,4-dihydropyrimidin-2(1H)-one 

Relevant articles and documents

H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.

Aerobic oxygenation of α-methylene ketones under visible-light catalysed by a CeNi3complex with a macrocyclic tris(salen)-ligand

A hetero-tetranuclear CeNi3 complex with a macrocyclic ligand catalysed the aerobic oxygenation of a methylene group adjacent to a carbonyl group under visible-light radiation to produce the corresponding α-diketones. The visible-light induced homolysis of the Ce-O bond of a bis(enolate) intermediate is proposed prior to aerobic oxygenation.

Ruthenium(II)-Catalyzed Cross-Coupling of Benzoyl Formic Acids with Toluenes: Synthesis of 2-Phenylacetophenones

Herein, we report a direct method to synthesize 2-phenylacetophenone through a ruthenium(II)-catalyzed cross-coupling reaction between acyl and benzyl radical. The various derivatives of 2-phenylacetophenone were prepared easily in moderate to good yields. These reactions provide a straightforward pathway to synthesize a variety of ketones bearing various functional groups.