Methyl 3-hydroxy-5-methoxybenzoate

Base Information

• Chemical Name: Methyl 3-hydroxy-5-methoxybenzoate
• CAS No.: 19520-74-2
• Molecular Formula: C9H10O4
• Molecular Weight: 182.176
• Hs Code.: 2918990090
• ChEMBL ID: CHEMBL2252110
• DSSTox Substance ID: DTXSID00552953
• Wikidata: Q82433392
• Mol file: 19520-74-2.mol

Synonyms:methyl 3-hydroxy-5-methoxybenzoate;19520-74-2;MFCD00601487;Benzoic acid, 3-hydroxy-5-methoxy-, methyl ester;3-Hydroxy-5-methoxybenzoic acid methyl ester;SCHEMBL55814;CHEMBL2252110;DTXSID00552953;methyl3-hydroxy-5-methoxybenzoate;MNWFENBPJIWZOZ-UHFFFAOYSA-N;AKOS006272525;CS-W022830;DS-7893;SY115267;3-methoxy-5-hydroxybenzoic acid methyl ester;3-hydroxy-5-methoxy-benzoic acid methyl ester;EN300-125340;A880152

Chemical Property of Methyl 3-hydroxy-5-methoxybenzoate

Chemical Property:

• Melting Point: 94-95 °C
• Boiling Point: 328.3±22.0 °C(Predicted)
• PKA: 8.77±0.10(Predicted)
• PSA: 55.76000
• Density: 1.216±0.06 g/cm3(Predicted)
• LogP: 1.18740
• Storage Temp.: 2-8°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 182.05790880
• Heavy Atom Count: 13
• Complexity: 181

Purity/Quality:

97% ^*data from raw suppliers

methyl3-hydroxy-5-methoxybenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)O)C(=O)OC

Technology Process of Methyl 3-hydroxy-5-methoxybenzoate

There total 16 articles about Methyl 3-hydroxy-5-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-acetoxy-5-methoxy-benzoic acid methyl ester (71094-48-9) → 3-hydroxy-5-methoxy-benzoic acid methyl ester (19520-74-2)

Guidance literature:

With methanol; sodium methylate; at 20 ℃; for 1h;

DOI:10.1055/s-2001-15076

Reference yield: 88.0%

methanol (67-56-1) + 3-hydroxy-5-methoxybenzoic acid (19520-75-3) → 3-hydroxy-5-methoxy-benzoic acid methyl ester (19520-74-2)

Guidance literature:

With sulfuric acid;

Reference yield: 75.0%

3,5-Dihydroxybenzoic acid (99-10-5) + dimethyl sulfate (77-78-1) → 3-hydroxy-5-methoxy-benzoic acid methyl ester (19520-74-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/ol501095w

upstream raw materials:

3,5-Dihydroxybenzoic acid

methyl iodide

methanol

3-hydroxy-5-methoxybenzoic acid

Downstream raw materials:

3-hydroxy-5-methoxybenzoic acid

methyl 3-(benzyloxy)-5-methoxybenzoate

Ethyl-3-benzyloxy-5-methoxybenzoat

methyl 3-(2-butenyloxy)-5-methoxybenzoate