19522-40-8

Usage

Uses

Used in Pharmaceutical Research:
D-GLUTAMIC ACID ALPHA-AMIDE HYDROCHLORIDE is used as a research compound for its potential to affect glutamate receptors, which are involved in various neurological processes. It is being studied for its role in the treatment of neurodegenerative diseases and conditions such as anxiety and depression.
Used in Organic Synthesis:
D-GLUTAMIC ACID ALPHA-AMIDE HYDROCHLORIDE is used as a chemical intermediate in the production of pharmaceuticals, contributing to the synthesis of various organic compounds.
Used in Neurological Research:
D-GLUTAMIC ACID ALPHA-AMIDE HYDROCHLORIDE is used as a research tool to explore its potential in modulating the function of glutamate receptors, which are implicated in learning and memory processes. This research aims to understand its impact on cognitive functions and its possible therapeutic applications in neurological disorders.

Upstream product

• 19522-39-5 (R)-5-amino-4-(((benzyloxy)carbonyl)amino)-5-oxopentanoic acid 
• 135941-75-2 α-cyclopentyl D-glutamate 
• 55297-72-8 (R)-5-amino-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid 
• 6893-26-1 D-Glutamic acid 
• 63648-73-7 N-benzyloxycarbonyl-D-glutamic acid 
• 18800-73-2 benzyl (R)-5-amino-4-((tert-butoxycarbonyl)amino)-5-oxopentanoate 
• 2578-33-8 D-glutamic acid-5-benzyl ester 
• 35793-73-8 N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid 
• 18800-76-5 Boc-D-Glu(OBzl)-OSu 
• 135941-74-1 dicyclopentyl D-glutamate 

Downstream Products

• 87137-45-9 γ-benzyl isoglutaminate perchlorate 
• 71811-14-8 D-Glutaminsaeure-α-amid-γ-benzylester 
• 292150-20-0 N-Fmoc-D-isoglutamine 

Relevant academic research and scientific papers

The synthesis of D-isoglutamine by A chemoenzymatic method

α-Cyclopentyl D-glutamate was obtained from dicyclopentyl D-glutamate utilizing lipase-catalyzed hydrolysis. The monoester was then treated with NH3 in methanol to produce D-isoglutamine.

A novel immunostimulator, N2-[α-O-Benzyl-N-(acetylmuramyl) -L-alanyl-D-isoglutaminyl]-N6-trans-(m-nitrocinnamoyl)-L-lysine, and its adjuvancy on the hepatitis B surface antigen

N2-[α-O-Benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl] -N6-trans-(m-nitrocinnamoyl)-L-lysine (muramyl dipeptide C, or MDP-C) has been synthesized as a novel, nonspecific immunomodulator. The present study shows that MDP-C induces

Solid-phase synthesis of muramyl dipeptide (MDP) derivatives using a multipin method

Solid-phase synthetic method of muramyl dipeptide derivatives is reported. A diverse library of muramyl dipeptides could be potentially synthesized by acylation, reductive alkylation, sulfonamide formation, urea formation, N-alkylation, amine addition, or component Ugi reactions based on this method for drug screening. (C) 2000 Elsevier Science Ltd. All rights reserved.

Synthesis of a Biologically Active Fluorescent Muramyl Dipeptide Congener

A fluorescent-labeled muramyl dipeptide (MDP) has been prepared to probe immunoadjuvant cellular interactions.N-Acetylmuramyl-L-alanyl-D-isoglutamine (1) was synthesized in improved yield and reacted with 2-(fluoroesceinylamino)-4,6-dichloro-s-triazine (DTAF,2) to give the fluorescent adduct DTAF-MDP (3), attached through the 6-position of the sugar moiety.Adjuvant activity was assessed by using two different in vitro assays, macrophage spreading, and inhibition of macrophage migration.Both assays indicated that the apparent adjuvant activity of 3 is comparable to that of 1.