19523-57-0Relevant academic research and scientific papers
Formylation and acetylation of 2-ethoxynaphthalene with 1,3,5-triazines in polyphosphoric acid
Aksenov,Aksenova,Borovlev,Zamorkin
, p. 215 - 216 (2008)
Heating of 2-ethoxynaphthalene with 1,3,5-triazine or 2,4,6-trimethyl-1,3, 5-triazine in polyphosphoric acid leads to the corresponding products of mono- or diacylation: 2-ethoxy-naphthalene-1-carbaldehyde, 1-acetyl-2- ethoxynaphthalene, 2-ethoxynaphthale
Synthesis, characterization, and anti-cancer activity of new chalcone derivatives containing naphthalene and fluorine moieties
Lim, Yeong Hui,Oo, Chuan Wei,Koh, Rhun Yian,Voon, Gah Leong,Yew, Mei Yeng,Yam, Mun Fei,Loh, Yean Chun
, p. 994 - 1003 (2020/07/30)
In recent years, chalcones and their derivatives have become the focus of global scientists due to increasing evidence reported towards their potency in antitumor and anti-cancer. Here, the chalcones designed and synthesized in our present study were derived from the derivatives of naphthaldehyde and acetophenone. Both these precursors have been reported in demonstrating a certain degree of anticancer property. Also, the substituents on these precursors such as hydroxyl, methoxy, prenyl, and chloro were shown able to enhance the anticancer efficiency. Hence, it is the interest of the current study to investigate the anticancer potential of the hybrid molecules (chalcones) consisting of these precursors with different alkoxy substituents and with or without the fluorine moiety. Two series of chalcone derivatives were designed, synthesized, and characterized using the elemental analysis, IR, 1H and 13C NMR spectroscopy, subsequently evaluated for their anti-cancer activity. Interestingly, the results showed that the fluorinated chalcones 11–15 exhibited stronger cytotoxic activity towards the breast cancer cell lines (4T1) compared to non-fluorinated chalcone derivatives. Remarkably, the selectivity index obtained for these fluorinated chalcones derivatives against the breast cancer 4T1 cell line was higher than those exhibited by cisplatin, which is one of the most frequently deployed chemotherapy agents in current medical practice. These findings could provide an insight towards the potential of fluorinated chalcones being developed as an anti-cancer agent with moderate activity towards breast cancer cell and low inhibition of fibroblast cell at a concentration of 100 μM.
A pharmaceutical intermediate nafcillin sodium 2-ethoxy-1-naphthalene formaldehyde synthesis method (by machine translation)
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Paragraph 0015; 0016, (2016/12/01)
A pharmaceutical intermediate nafcillin sodium 2-ethoxy-1-naphthalene formaldehyde synthetic method, comprising the following steps: in mounting a stirrer, thermometer, dropping funnel in the reaction container, adding 1-amino-2- ethoxy group naphthalene solution 1.3mol, 1-hydroxy -1 methyl-carboxamide solution the 1.5 [...] 1.8mol, cyclonexane 500 ml, alumina 0.6mol, control the stirring speed of the 110 [...] 160rpm, raising the temperature of the solution to 60 - - 67°C, reaction 5 the [...] 7h, raising the temperature of the solution to 80 - - 85°C, continue to react the 110 [...] 130 min, reducing the temperature of the solution to 10 - - 15°C, by adding potassium bromide solution 300 ml, then the 30 [...] 35h, precipitated solid, filtered, salt solution washing, washing ethyl acetate, acetonitrile washing, dehydrating agent dehydration, the recrystallization in triethylamine, to obtain crystal 2-ethoxy-1-naphthalene formaldehyde. (by machine translation)
Chiroptical inversion induced by rotation of a carbon-carbon single bond: An experimental and theoretical study
Lu, Wei,Du, Ganhong,Liu, Keyuan,Jiang, Liming,Ling, Jun,Shen, Zhiquan
, p. 283 - 292 (2014/02/14)
We propose a new strategy to construct chiral molecular switches with highly reversible and sensitive chiroptical responses to variations in the external environment. Its fundamental concept involves a stimuli-triggered exchange of two conformations presenting significantly different chiroptical properties through the rotation of a carbon-carbon single bond, as demonstrated by chiral Schiff bases s-1, s-2, and a salicylamide analogue s-3. Upon addition of base in solution, the circular dichroism (CD) spectra of these molecular switches displayed unique changes featuring an inversion of the Cotton effect's signs, and the original CD profiles can be recoverd by acidification. Various spectroscopic studies as well as the conformational analysis combining with TDDFT computations allowed clear elucidation of the chiroptical inversion mechanism. It is expected that this kind of chiroptical switches is of great interest for molecular recognition, chemosensing, and the construction of molecular-scale devices. Furthermore, the present study indicates that the use of the conformational transition about a single bond may serve as the basis for designing chiroptical inversion systems.
4,4'-Binaphthylidene-1,1'-diones - Colour and Structure
Kral, Andreas,Laatsch, Hartmut
, p. 1401 - 1407 (2007/10/02)
Synthesis and properties of various 4,4'-binaphthylidene-1,1'-diones are described.The UV spectra of the deep red to purple diones may be calculated on the base of substituent increments.The experimental values of the analyzed substituents can be reproduced using PPP calculations with satisfying accuracy, which makes it possible to predict also absorption maxima of hitherto unknown 4,4'-binaphthylidene-1,1'-diones.Keywords: 4,4'-Binaphthylidene-1,1'-diones, Phenol Oxidation
Hypoglycemic 5-substituted oxazolidine-2,4-diones
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, (2008/06/13)
Hypoglycemic 5-phenyl and 5-naphthyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.
