1953-63-5Relevant academic research and scientific papers
Cs2CO3 Catalyzed Intramolecular Aminocarbonylation of Alkynes: Synthesis of 3-Amino-1H-inden-1-ones from N-tert-Butyl-2-(1-alkynyl)benzaldimines
Guo, Zhen,Liu, Tao,Liang, Xiujuan,Wu, Yuting,Yao, Tuanli
, p. 1053 - 1057 (2020)
Synthesis of a wide variety of 3-amino-1H-inden-1-ones from N-tert-butyl-2-(1-alkynyl)benzaldimines via intramolecular aminocarbonylation of alkynes using Cs2CO3 as catalyst and air as oxidant has been developed. This highly atom-efficient, transition-metal-free reaction proceeds under thermal conditions. We propose that the reaction proceeds through an unprecedented 5-exo-dig cyclization of N-tert-butyl-2-(1-alkynyl)benzaldimines and thermal rearrangement of 3-methylene-2λ2-isoindolin-1-ols. (Figure presented.).
