Triarylmethyl substituted 4,5-dicyanoimidazoles as activators for Rp- diastereoselective synthesis of TpN dinucleoside methylphosphonates

Article abstract of DOI:10.1080/07328319908044654

2-Triarylmethyl-4,5-dicyanoimidazoles 1-3 were synthesized and tested as activators in the methylphosphonamidite approach. TpN dinucleoside methylphosphonates generated showed diastereoselectivity of up to 8/1 (Rp/Sp). The influence of the different triarylmethyl substituents on diastereoselectivity is shown.

Full text of DOI:10.1080/07328319908044654

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Nucleosides and Nucleotides
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Triarylmethyl Substituted 4,5-
Dicyanoimidazoles as Activators for Rp-
Diastereoselective Synthesis of TpN
Dinucleoside Methylphosphonates
Peter Schell a , Wolfgang H. G. Laux a & Joachim W. Engels a
a Johann Wolfgang Goethe-Universität, Institut für Organische
Chemie, Marie-Curie-Str. 11, D-60439, Frankfurt/Main, Germany
Published online: 04 Oct 2006.
To cite this article: Peter Schell , Wolfgang H. G. Laux & Joachim W. Engels (1999) Triarylmethyl
Substituted 4,5-Dicyanoimidazoles as Activators for Rp-Diastereoselective Synthesis of TpN
Dinucleoside Methylphosphonates, Nucleosides and Nucleotides, 18:6-7, 1169-1174
To link to this article: http://dx.doi.org/10.1080/07328319908044654
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