195316-41-7Relevant articles and documents
Synthetic studies of halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. 6. Synthesis of the C1 - C15 unit via stereoselective construction of the B and A rings by kinetically and thermodynamically controlled Michael reactions with the aid of computational search for dominant conformers
Horita, Kiyoshi,Hachiya, Shun-Ichiro,Yamazaki, Tatsuya,Naitou, Tae,Uenishi, Jun'ichi,Yonemitsu, Osamu
, p. 1265 - 1281 (2007/10/03)
The C1 - C15 unit of halichondrin B was synthesized starting from D- glucose via stereoselective construction of the B and A rings, which have 2,6-trans- and 2,6-cis-disubstituted tetrahydropyran rings, respectively. With the aid of MM2 calculations kinetically and thermodynamically controlled Michael reactions were successfully applied for the construction of the B and A rings, respectively.