19532-98-0

Basic information

• Product Name: Milnacipran Related Impurity 3
• Synonyms: Milnacipran Related Impurity 3;N,N-Dimethylphthalamide;N1,N2-dimethylphthalamide;N1,N2-Dimethyl-1,2-benzenedicarboxamide
• CAS NO: 19532-98-0
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.21448
• Mol File: 19532-98-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 185 °C (decomp)
• Boiling Point: 453.0±28.0 °C(Predicted)
• Appearance: /
• Density: 1.129±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Very Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 14.12±0.46(Predicted)
• Stability: Moisture Sensitive
• CAS DataBase Reference: Milnacipran Related Impurity 3(CAS DataBase Reference)
• NIST Chemistry Reference: Milnacipran Related Impurity 3(19532-98-0)
• EPA Substance Registry System: Milnacipran Related Impurity 3(19532-98-0)

Safety Data

• Hazardous Substances Data: 19532-98-0(Hazardous Substances Data)

Usage

Uses

N,N''-Dimethylphthalamide is a impurity derived from phthalamide (P384550). Phthalimide is a reagent used to transform allyl- and alkyl halides into protected primary amines. Phthalimide analogues have been extensively used in medicinal chemistry owing to their wide spectrum of applications as anti-convulsant, anti-inflammatory, analgesic, hypolipidimic and immunomodulatory activities.

Upstream product

• 88-95-9 Phthaloyl dichloride 
• 74-89-5 methylamine 
• 925670-73-1 (E)-3-(1-oxo-1-(p-tolyl)propan-2-ylidene)isobenzofuran-1(3H)-one 
• 31583-38-7 tert-butyl 1,4-dioxo-1,4-dihydro-3H-benzo[d][1,2]oxazine-3-carboxylate 
• 1445745-29-8 N-methyl N'-(6'-hydroxyhexyl)phthalicdiamide 
• 56788-11-5 N-methyl-phthalamide 
• 550-44-7 N-methylphthalimide 
• 5394-18-3 2-(4-bromobutyl)isoindoline-1,3-dione 
• 4702-13-0 N-phthaloylglycine 
• 5022-29-7 N-ethylphthalimide 
• 524-38-9 N-hydroxyphthalimide 
• 136918-14-4 phthalimide 
• 22011-24-1 N,N'-diethylphthalic diamide 
• 7732-18-5 water 

Downstream Products

• 56788-11-5 N-methyl-phthalamide 
• 550-44-7 N-methylphthalimide 

Relevant articles and documents

Preparation method of impurities during synthesis of rivaroxaban

The invention discloses a preparation method of impurities during the synthesis of rivaroxaban, and belongs to the field of chemical pharmacy. The impurities comprise an impurity A, an impurity B, animpurity C and an impurity D. The invention further comp

PROTECTED LINKER COMPOUNDS

The invention features protected linker compounds which comprise at one terminus a protected amino group and at another other terminus a phosphorous activating group, such as a phosphoramidite group. These protected linker compounds are introduced chemically at the 5'-end of oligonucleotides for the purpose of preparing 5'-amino modified oligonucleotides. After deprotection, the thereby introduced amino group then allows further modification (e.g. attachment of dyes) or immobilization (on surfaces or beads) of the oligonucleotide. Specifically, the presented amino protecting group is designed to provide such protected linker compounds in a solid form, which facilitates efficient purification by precipitation or crystallization and aliquoting for distribution and storage.

THIOETHER PROTECTION VIA SELECTIVELY CLEAVABLE SULFONIUM SALTS

There are few protecting groups available for the thioether functionality.The selective cleavage of 4-phthalimidobutyl- and p-methoxybenzylsulfonium salts make these derivatives ideal for thioether protection.