19544-43-5

Usage

Uses

Used in Polymer Synthesis:
BENZYL BUTANEDIOIC ACID ANHYDRIDE is used as a monomer for the synthesis of polymers, contributing to the creation of various types of polymeric materials with specific properties tailored for different applications.
Used in Resin and Adhesive Production:
In the manufacturing industry, BENZYL BUTANEDIOIC ACID ANHYDRIDE is utilized as a crosslinking agent in the production of resins and adhesives. Its role in crosslinking enhances the strength and durability of these materials, making them suitable for a wide range of uses.
Used in Pharmaceutical Manufacturing:
BENZYL BUTANEDIOIC ACID ANHYDRIDE is employed in the pharmaceutical sector as an intermediate in the synthesis of various pharmaceuticals. Its chemical properties make it a valuable component in the development of new drugs and medicinal compounds.
Used in Agricultural Chemical Production:
BENZYL BUTANEDIOIC ACID ANHYDRIDE also finds application in agriculture, where it is used in the production of agricultural chemicals. Its role in this industry is crucial for the development of effective and efficient products for crop protection and enhancement.

Upstream product

• 108-31-6 maleic anhydride 
• 103-50-4 dibenzyl ether 
• 108-88-3 toluene 
• 109554-51-0 3-phenyl-1,2,2-propanetricarboxylic acid 1,2,2-triethyl ester 
• 770-09-2 benzyltrimethylsilane 
• 4436-24-2 1,2-epoxy-3-phenylpropane 
• 201230-82-2 carbon monoxide 
• 42361-63-7 3-phenyl-propane-1,2,2-tricarboxylic acid 
• 5653-88-3 trans-phenylitaconic acid 
• 36092-42-9 2-benzylsuccinic acid 
• 451-40-1 phenyl benzyl ketone 
• 23215-60-3 2-benzyl-2-phenylbenzothiazoline 
• 80459-39-8 dimethyl-2-benzylidenesuccinate 
• 100-52-7 benzaldehyde 

Downstream Products

• 103036-32-4 3-benzyl-1-hexadecyl-pyrrolidine-2,5-dione 
• 101105-22-0 3-benzyl-1-butyl-pyrrolidine-2,5-dione 
• 103402-97-7 3-benzyl-1-octadecyl-pyrrolidine-2,5-dione 
• 6566-40-1 4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid 

Relevant academic research and scientific papers

Benzothiazolines as radical transfer reagents: Hydroalkylation and hydroacylation of alkenes by radical generation under photoirradiation conditions

Novel radical transfer reagents under photoirradiation conditions were developed by the use of benzothiazoline derivatives. These reagents enabled both hydroalkylation and hydroacylation of alkenes under neutral conditions at ambient temperature without a

Triflic Acid Mediated Cyclization of Unsymmetrical N -Phenethyl- and N -(3-Indolylethyl)succinimides: Regio- and Diastereoselective Synthesis of Substituted Pyrroloisoquinolinones and Indolizino-indolones

The regio and diastereoselective synthesis of 1 or 2 alkyl-substituted pyrroloisoquinolinones and indolizinoindolones by triflic acid mediated cyclization via an electrophilic activation of unsymmetrical succinimide carbonyl groups followed by the reducti

Succinic anhydrides from epoxides

Catalysts and methods for the double carbonylation of epoxides are disclosed. Each epoxide molecule reacts with two molecules of carbon monoxide to produce a succinic anhydride. The reaction is facilitated by catalysts combining a Lewis acidic species with a transition metal carbonyl complex. The double carbonylation is achieved in single process by using reaction conditions under which both carbonylation reactions occur without the necessity of isolating or purifying the product of the first carbonylation.

PYRROLIDIN-2-ONES AS HDM2 LIGANDS

The present invention provides compounds of formula (I) or (Ia) which are ligands binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (I) or (I

Catalytic double carbonylation of epoxides to succinic anhydrides: Catalyst discovery, reaction scope, and mechanism

The first catalytic method for the efficient conversion of epoxides to succinic anhydrides via one-pot double carbonylation is reported. This reaction occurs in two stages: first, the epoxide is carbonylated to a β-lactone, and then the β-lactone is subsequently carbonylated to a succinic anhydride. This reaction is made possible by the bimetallic catalyst [(CITPP)Al(THF)2]+[Co(CO)4]- (1; CITPP = meso-tetra(4-chlorophenyl)porphyrinato; THF = tetrahydrofuran), which is highly active and selective for both epoxide and lactone carbonylation, and by the identification of a solvent that facilitates both stages. The catalysis is compatible with substituted epoxides having aliphatic, aromatic, alkene, ether, ester, alcohol, nitrile, and amide functional groups. Disubstituted and enantiomerically pure anhydrides are synthesized from epoxides with excellent retention of stereochemical purity. The mechanism of epoxide double carbonylation with 1 was investigated by in situ IR spectroscopy, which reveals that the two carbonylation stages are sequential and non-overlapping, such that epoxide carbonylation goes to completion before any of the intermediate β-lactone is consumed. The rates of both epoxide and lactone carbonylation are independent of carbon monoxide pressure and are first-order in the concentration of 1. The stages differ in that the rate of epoxide carbonylation is independent of substrate concentration and first-order in donor solvent, whereas the rate of lactone carbonylation is first-order in lactone and inversely dependent on the concentration of donor solvent. The opposite solvent effects and substrate order for these two stages are rationalized in terms of different resting states and rate-determining steps for each carbonylation reaction.

Nitroalkanes and dimethyl maleate as source of 3-alkyl succinic anhydrides and (E)-3-alkylidene succinic anhydrides

Nitroalkanes react with dimethyl maleate giving a tandem Michael addition/elimination of nitrous acid. The obtained (E)-2-alkylidene dimethyl succinates are: (i) reduced to the corresponding 2-alkyl dimethyl succinates which after hydrolysis produce 1,4-dicarboxylic acids that are prone to convert into the corresponding 3-alkyl succinic anhydrides or (ii) hydrolysed to (E)-2-alkylidene-succinic acids that are easily cyclised to (E)-3-alkylidene succinic anhydrides.

Synthesis of monosubstituted succinic acids from tert-butylsuccinate

We report the preparation and alkylation of the dianion of t-butylsuccinate. This alkylation reaction has proven to be a useful method for the preparation of monosubstituted succinic acids and anhydrides.

Inhibitors of microsomal triglyceride transfer protein and method

Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure STR1 wherein R1 to R7, Q, X and Y are as defined herein.

Titanium dioxide photocatalysed alkylation of maleic acid derivatives

The irradiation of a nitrogen-flushed acetonitrile suspension of titanium dioxide in the presence of benzyltrimethylsilane, its 4-methoxy derivative or 4-methoxyphenylacetic acid as the donors and maleic acid, maleic anhydride or related nitriles as the accepters leads to the corresponding benzylsuccinic acid derivatives via electron, hole transfer and fragmentation of the benzyl radical cation (such a cleavage is too slow with 4-methoxytoluene). A rationale of the reaction and an evaluation of the synthetic significance of the method are given.

Nucleic acids encoding microsomal trigyceride transfer protein

Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.