1955-04-0Relevant articles and documents
Contrast agent iopromide intermediate as well as preparation method and application thereof
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Paragraph 0031; 0037; 0041, (2021/05/29)
The invention discloses a contrast agent iopromide intermediate as well as a preparation method and application thereof, and belongs to the technical field of organic chemistry. The iopromide intermediate is N-(2, 3-dihydroxy-propyl)-5-nitroisophthalic acid methyl ester. According to the preparation method, the iopromide intermediate is synthesized through two steps, the product obtained in the reaction in the step (1) can directly participate in the reaction in the step (2) without a complex purification process, the product obtained in the step (2) does not need a time-consuming, labor-consuming and money-consuming purification method such as column chromatography and does not need a recrystallization method which can cause a great loss of the product, the high-purity iopromide intermediate can be obtained only through simple extraction, the purity is larger than 99.5%, and the yield can reach 70-80%. Therefore, when the intermediate is used for preparing iopromide, the price of iopromide can be greatly reduced.
Preparation methods of iopromide and intermediate of iopromide
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Paragraph 0058-0060, (2018/03/24)
The application of the invention relates to preparation methods of iopromide and an intermediate of the iopromide. The method specifically comprises the following steps: conducting a reduction reaction, an iodination reaction and an acylation reaction on a compound shown in the formula VI to prepare a compound shown in the formula III, and further preparing to obtain the iopromide. The method notonly avoids the generation of double acylation byproducts, but also effectively reduces the generation of byproducts in the preparation process, the intermediate is easy to separate and purify, and ahigh-purity product is obtained at a relatively high yield.
Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold
Tsou, Lun K.,Dutschman, Ginger E.,Gullen, Elizabeth A.,Telpoukhovskaia, Maria,Cheng, Yung-Chi,Hamilton, Andrew D.
scheme or table, p. 2137 - 2139 (2010/06/22)
A potential anti-HIV and HCV drug candidate is highly desirable as coinfection has become a worldwide public health challenge. A potent compound based on a tetrabutoxy-calix[4]arene scaffold that possesses dual inhibition for both HIV and HCV is described. Structural activity relationship studies demonstrate the effects of lower-rim alkylation in maintaining cone conformation and upper-rim interacting head groups on the calix[4]arene play key roles for its potent dual antiviral activities.