19550-57-3

Basic information

• Product Name: 6,7-DIMETHYL-1-TETRALONE
• Synonyms: AKOS BC-0653;6,7-DIMETHYL-1-TETRALONE;3,4-Dihydro-6,7-dimethyl-1(2H)-naphthalenone;6,7-Dimethyltetralin-1-one;6,7-dimethyl-3,4-dihydro-2H-naphthalen-1-one;6,7-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one
• CAS NO: 19550-57-3
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.24
• Mol File: 19550-57-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 46.0 to 50.0 °C
• Boiling Point: 130°C/2mmHg(lit.)
• Flash Point: 137.5°C
• Appearance: /
• Density: 1.054g/cm³
• Vapor Pressure: 0.000348mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 6,7-DIMETHYL-1-TETRALONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DIMETHYL-1-TETRALONE(19550-57-3)
• EPA Substance Registry System: 6,7-DIMETHYL-1-TETRALONE(19550-57-3)

Safety Data

• Hazardous Substances Data: 19550-57-3(Hazardous Substances Data)

Usage

General Description

6,7-Dimethyl-1-tetralone is a chemical compound with the molecular formula C11H14O. It is a colorless liquid with a faint odor, and it is used in the synthesis of various pharmaceuticals and organic compounds. This chemical is commonly utilized in research and development settings as a precursor for the preparation of other organic molecules. It is known for its ability to undergo a variety of chemical reactions, making it versatile for use in different applications. Additionally, 6,7-Dimethyl-1- tetralone may also have potential applications in the field of organic synthesis and drug discovery due to its unique chemical properties.

InChI:InChI=1/C12H14O/c1-8-6-10-4-3-5-12(13)11(10)7-9(8)2/h6-7H,3-5H2,1-2H3

Upstream product

• 5465-18-9 γ-(3,4-dimethylphenyl)butyric acid 
• 77970-19-5 6,7-Dimethyl-3,4,5,8-tetrahydro-2H-naphthalen-1-one 
• 51036-98-7 3-(3,4-dimethylbenzoyl)propionic acid 
• 95-47-6 o-xylene 
• 64959-04-2 7-cyclohexyl-3,4-dihydro-1(2H)-naphthalenone 
• 854871-04-8 4-(3,4-dimethyl-phenyl)-butyryl chloride 
• 96-48-0 4-butanolide 

Downstream Products

• 2245-38-7 1,6,7-trimethylnaphthalene 
• 51036-99-8 1-Phenyl-6,7-dimethyl-3,4-dihydronaphthalin 
• 181129-90-8 1-[2-(6,7-Dimethyl-naphthalen-1-yl)-ethyl]-4-methyl-2-oxo-cyclohexanecarboxylic acid ethyl ester 
• 110148-57-7 2,3-Dimethyl-5-benzyl-naphthalin 
• 31776-14-4 6,7-dimethyl-1-naphthol 

Relevant articles and documents

Synthesis of Novel Pterocarpen Analogues via [3?+?2] Coupling-Elimination Cascade of α,α-Dicyanoolefins with Quinone Monoimines

By employing triethylamine as a catalyst, [3?+?2] coupling-elimination cascade of α,α-dicyanoolefins with quinone monoimines was realized. The reactions afforded various novel pterocarpen analogues with generally moderate yields (up to 75%). In addition, a plausible reaction mechanism was proposed.

Highly enantioselective [3+2] coupling of cyclic enamides with quinone monoimines promoted by a chiral phosphoric acid

Enantioselective [3+2] coupling of cyclic enamides with quinone monoimines was realised using a chiral phosphoric acid as a catalyst. This transformation allowed for the synthesis of highly enantioenriched polycyclic 2,3-dihydrobenzofurans (up to 99.9% ee). The absolute configuration of one product was determined by an X-ray crystal structural analysis. We also found a possible mechanism for this reaction.

Synthesis of (±)-7,8- and 5,6-dimethyl-2-(2-hydroxyisopropyl) tetralins

7,8-Dimethyl-l-tetralone 4 on sodium borohydride reduction followed by Vilsmeier-Haack reaction furnishes 7, 8-dimethyl-3,4-dihydro-2-naphthaldehyde 10. Reduction of 10 followed by oxidation with Jones reagent yields 7, 8-dimethyl-1,2,3,4-tetrahydro-2-naphthoic acid 12 which on treatment with excess of methyllithium affords 7, 8-dimethyl-2-(2-hydroxyisopropyl) tetralin 2. 5,6-dimethyl-l-tetralone 5 is converted into the 5,6-dimethyl-2-(2-hydroxyisopropyl)tetralin 3 by following similar set of reactions as described above.