195525-45-2Relevant academic research and scientific papers
Pyrrolidinones derived from (S)-pyroglutamic acid. Part 3. β-Aminopyrrolidinones
Chan,Cottrell,Moloney
, p. 2997 - 3006 (2001)
The conjugate addition of activated nitrogen nucleophiles, such as hydroxylamine and hydrazine derivatives, to α, β-unsaturated bicyclic lactam 1a gave the corresponding β-amino products 9a-g in good yield and excellent diastereo- selectivity. These products can be manipulated to afford enantiopure β-aminopyrrolidinones of potential application as conformationally-constrained, substituted glutamate templates of well-defined stereochemistry.
Conjugate addition of nitrogen nucleophiles to an α,β-unsaturated pyrrolidinone
Chan, Philip W. H.,Cottrell, Ian F.,Moloney, Mark G.
, p. 5891 - 5894 (2007/10/03)
The conjugate addition of nitrogen nucleophiles to α,β-unsaturated lactam 1b under very mild conditions occurs in good yield with high diastereoselectivity. Deprotection provides a simple access to β-aminopyrrolidinones in excellent overall yield.
