195611-65-5Relevant academic research and scientific papers
Facile synthesis of O6-alkyl-, O6-aryl-, and diaminopurine nucleosides from 2′-deoxyguanosine
Lakshman, Mahesh K.,Ngassa, Felix N.,Keeler, John C.,Dinh, Yen Q. V.,Hilmer, John H.,Russon, Larry M.
, p. 927 - 930 (2000)
(equation presented) The 3′,5′-bis-O-TBDMS derivative of 2′-deoxyguanosine can be converted to its O6-alkyl and O6-aryl ethers as well as to N6-substituted diaminopurine nucleosides in two simple steps. Also described is a
One-pot etherification of purine nucleosides and pyrimidines
Kokatla, Hari Prasad,Lakshman, Mahesh K.
supporting information; experimental part, p. 4478 - 4481 (2010/12/24)
A one-pot synthesis of ethers derived from inosine, guanosine, 2′-deoxyguanosine, and pyrimidinones is described. Exposure of the heterocycle to 1H-benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and Cs2CO3/s
A simple method for C-6 modification of guanine nucleosides
Lakshman, Mahesh K.,Frank, Josh
, p. 2933 - 2940 (2011/04/17)
A facile method for the introduction of various substituents at the C-6 position of guanosine and 2′-deoxyguanosine is reported. In a simple, 1-step transformation, tert-butyldimethylsilyl protected guanosine and 2′-deoxyguanosine were converted to the O
Synthesis of an N-Alkyl Derivative of 2′-Deoxywoguanosine
Kodra, Janos T.,Benner, Steven A.
, p. 939 - 940 (2007/10/03)
3′,5′-O-bis-tert-butyldimethylsilyl-2′-deoxyguanosine is converted in two steps to 3′,5′-O-tert-butyldimethylsilyl-6-O-aryl-2′-deoxyxanthosine. This compound is used to make a 2′-deoxyisoguanosine analog with a functionalized side chain.
