195718-80-0Relevant academic research and scientific papers
α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors
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, (2008/06/13)
The present application describes m-amidino phenyl analogs of formula I: wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.
Rational design and synthesis of novel, potent bis-phenylamidine carboxylate factor Xa inhibitors
Maduskuie Jr., Thomas P.,McNamara, Kevin J.,Yu, Ru,Knabb, Robert M.,Stouten, Pieter F. W.
, p. 53 - 62 (2007/10/03)
The molecular modeling studies, rational design, and synthesis of a novel series of bis-phenylamidine carboxylate compounds which are inhibitors of factor Xa in the blood coagulation cascade are described. Inhibition of blood coagulation has been proposed
