58949-77-2

Upstream product

• 1443-80-7 4-cyanophenyl methyl ketone 
• 105-07-7 4-cyanobenzaldehyde 
• 874-89-5 4-Cyanobenzyl alcohol 
• 874-86-2 4-cyanobenzyl chloride 
• 58949-72-7 C₁₇H₁₂N₂O₂ 

Downstream Products

• 55368-75-7 1,3-bis(4-cyanophenyl)isoxazole 
• 55368-72-4 4,4'-(1H-pyrazole-3,5-diyl)dibenzonitrile 
• 195718-80-0 methyl 3-(4-cyanophenyl)-5-(4-cyanophenyl)pentanoate 
• 229308-73-0 1,3-bis(4-cyanophenyl)-2,3-dibromopropan-1-one 
• 61625-49-8 1,3-Bis-(4-amidinophenyl)-1-propanone 
• 62584-98-9 1,3-Bis(4-cyanophenyl)-1-propanone 
• 229308-74-1 2,4-bis(4-cyanophenyl)furan 

Relevant academic research and scientific papers

Biosynthesis of ZrO2 for ZrO2@Ag-S-CH2COOH as the retrievable catalyst for the one-pot green synthesis of pyrazoline derivatives and their anticancer evaluation

In the present work, Ficus benghalensis leaf extract was used for the synthesis of ZrO2 nanoparticles. Further, ZrO2@Ag-S-CH2-COOH was synthesized using biosynthesized ZrO2, and its catalytic potential was examined in the synthesis of pyrazoline from reaction of chalcone and hydrazine hydrate at room temperature. The structural conformation of ZrO2@Ag-S-CH2-COOH has been done using FT-IR, SEM, EDX, XRD, TGA-TDA, XPS, and DLS techniques, high turnover number (TON), and high turnover frequency. The ZrO2@Ag-S-CH2-COOH demonstrated outstanding catalytic activity for the synthesis of pyrazolines. The structures of the pyrazoline derivatives were confirmed by FT-IR, 1H and 13C NMR, and mass spectrometry techniques. Synthesized pyrazoline were tested for anticancer activity against human lung cancer cell line A549 study and confirmed by molecular docking investigations.

Synthesis and Characterization of Novel Mono- And Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult

Acid-sensitive ion channels (ASICs) are sodium channels partially permeable to Ca2+ions, listed among putative targets in central nervous system (CNS) diseases in which a pH modification occurs. We targeted novel compounds able to modulate ASIC1 and to reduce the progression of ischemic brain injury. We rationally designed and synthesized several diminazene-inspired diaryl mono- and bis-guanyl hydrazones. A correlation between their predicted docking affinities for the acidic pocket (AcP site) in chicken ASIC1 and their inhibition of homo- and heteromeric hASIC1 channels in HEK-293 cells was found. Their activity on murine ASIC1a currents and their selectivity vs mASIC2a were assessed in engineered CHO-K1 cells, highlighting a limited isoform selectivity. Neuroprotective effects were confirmedin vitro, on primary rat cortical neurons exposed to oxygen-glucose deprivation followed by reoxygenation, andin vivo, in ischemic mice. Early lead 3b, showing a good selectivity for hASIC1 in human neurons, was neuroprotective against focal ischemia induced in mice.

2,4-Diphenyl furan diamidines as novel anti-Pneumocystis carinii pneumonia agents

Dicationic 2,4-bis(4-amidinophenyl)furans 5-10 and 2,4-bis(4- amidinophenyl)-3,5-dimethylfurans 14 and 15 have been synthesized. Thermal melting studies revealed high binding affinity of the compounds to poly(dA- dT) and to the duplex oligomer d(CGCGAATTC

α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors

The present application describes m-amidino phenyl analogs of formula I: wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.

Rational design and synthesis of novel, potent bis-phenylamidine carboxylate factor Xa inhibitors

The molecular modeling studies, rational design, and synthesis of a novel series of bis-phenylamidine carboxylate compounds which are inhibitors of factor Xa in the blood coagulation cascade are described. Inhibition of blood coagulation has been proposed