19579-40-9

Basic information

• Product Name: 2-(4-bromophenyl)-1-(diaminomethylidene)guanidine hydrochloride
• Synonyms: {[(4-bromoanilino)(imino)methyl]amino}methanimidamide hydrochloride; 1-(4-Bromophenyl)biguanide hydrochloride; imidodicarbonimidic diamide, N-(4-bromophenyl)-, hydrochloride (1:1); N-(4-Bromophenyl)imidodicarbonimidic diamide hydrochloride (1:1)
• CAS NO: 19579-40-9
• Molecular Formula: C₈H₁₀BrN₅*ClH
• Molecular Weight: 292.5634
• Mol File: 19579-40-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 442.6°C at 760 mmHg
• Flash Point: 221.5°C
• Vapor Pressure: 4.94E-08mmHg at 25°C
• CAS DataBase Reference: 2-(4-bromophenyl)-1-(diaminomethylidene)guanidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)-1-(diaminomethylidene)guanidine hydrochloride(19579-40-9)
• EPA Substance Registry System: 2-(4-bromophenyl)-1-(diaminomethylidene)guanidine hydrochloride(19579-40-9)

Safety Data

• Hazardous Substances Data: 19579-40-9(Hazardous Substances Data)

Usage

General Description

2-(4-bromophenyl)-1-(diaminomethylidene)guanidine hydrochloride is a chemical compound that is used in scientific research and studies. It is a guanidine derivative, which is a class of compounds known for their potential biological and pharmacological activities. This particular compound contains a bromophenyl group and a diaminomethylidene group, and exists in the form of a hydrochloride salt. It may be used as a reagent in chemical reactions, or as a reference standard in analytical testing. Overall, this compound has the potential to be used in various applications within the scientific and research community.

Upstream product

• 127099-85-8 N-Cyanoguanidine 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 102557-26-6 1-(4-bromo-phenyl)-6-methyl-6-(2-morpholin-4-yl-ethyl)-1,6-dihydro-[1,3,5]triazine-2,4-diamine 
• 101250-96-8 N-(4-bromophenyl)-1-carbamimidamidomethanimidamide 
• 521064-34-6 6-(5-chloro-2-methylphenyl)-N²-(4-bromophenyl)-1,3,5-triazine-2,4-diamine 
• 101500-20-3 1-(4-bromo-phenyl)-6-methyl-6-morpholin-4-ylmethyl-1,6-dihydro-[1,3,5]triazine-2,4-diamine 

Relevant articles and documents

Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT-β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2

By screening a focused library of kinase inhibitor analogues in a phenotypic co-culture assay for angiogenesis inhibition, we identified an aminotriazine that acts as a cytostatic nanomolar inhibitor. However, this aminotriazine was found to be completely inactive in a whole-kinome profiling assay. To decipher its mechanism of action, we used the online target prediction tool PPB2 (http://ppb2.gdb.tools), which suggested lysophosphatidic acid acyltransferase β (LPAAT-β) as a possible target for this aminotriazine as well as several analogues identified by structure–activity relationship profiling. LPAAT-β inhibition (IC50 ≈15 nm) was confirmed in a biochemical assay and by its effects on cell proliferation in comparison with a known LPAAT-β inhibitor. These experiments illustrate the value of target-prediction tools to guide target identification for phenotypic screening hits and significantly expand the rather limited pharmacology of LPAAT-β inhibitors.

BIGUANIDE COMPOUND AND USE THEREOF

The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.