195830-41-2Relevant academic research and scientific papers
Palladium-Catalyzed Intramolecular Arylative Carboxylation of Allenes with CO2 for the Construction of 3-Substituted Indole-2-carboxylic Acids
Higuchi, Yuki,Mita, Tsuyoshi,Sato, Yoshihiro
, p. 2710 - 2713 (2017/05/24)
Arylative carboxylation of allenes proceeded in an intramolecular manner to afford the corresponding β,γ-unsaturated carboxylic acids in high yields using PdCl2/PAr3 (Ar = C6H4-p-CF3) and ZnEt2 under 1 atm of CO2. The intermediate of the cyclization/carboxylation sequence is thought to be a nucleophilic η1-allylethylpalladium, which reacts with CO2 at the γ-position of palladium. The products obtained could be efficiently converted into 3-substituted indole-2-carboxylate derivatives. One-pot synthesis of strychnocarpine, a β-carboline alkaloid, from the carboxylated product was also demonstrated.
Pd-Catalyzed Highly Regio- and Stereoselective Formation of C-C Double Bonds: An Efficient Method for the Synthesis of Benzofuran-, Dihydrobenzofuran-, and Indoline-Containing Alkenes
Gao, Yang,Xiong, Wenfang,Chen, Huoji,Wu, Wanqing,Peng, Jianwen,Gao, Yinglan,Jiang, Huanfeng
, p. 7456 - 7467 (2015/08/18)
A highly regio- and stereoselective C-C double bond formation reaction via Pd-catalyzed Heck-type cascade process with N-tosylhydrazones has been developed. Various N-tosylhydrazones derived from both ketones and aldehydes are found to be efficient substrates to provide di- and trisubstituted olefins with high regio- and stereoselectivity. Furthermore, this reaction has a good functional group tolerance and different benzofuran-, dihydrobenzofuran-, and indoline-containing alkene products were obtained with high selectivity.
Palladium catalysed tandem cyclisation-anion capture processes. Part 3. Organoboron anion transfer agents
Grigg, Ronald,Sansano, Jose M.,Santhakumar, Vijayaratnam,Sridharan, Visuvanathar,Thangavelanthum, Ravishanker,Thornton-Pett, Mark,Wilson, David
, p. 11803 - 11826 (2007/10/03)
The cyclisation-anion capture protocol has been applied to a wide range of starter and terminating species to effect regio- and stereo-specific mono- and bis-cyclisation processes in which a variety of organoboronderivatives function as anion transfer rea
