2076-36-0

Basic information

• Product Name: Methyl 3-methyl-2-benzofurancarboxylate
• Synonyms: methyl 3-methyl-2-benzofurancarboxylate;3-Methylbenzofuran-2-carboxylic acid methyl ester;methyl 3-methyl-1-benzofuran-2-carboxylate;methyl 3-methylbenzofuran-2-carboxylate
• CAS NO: 2076-36-0
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.2
• EINECS: 218-198-4
• Mol File: 2076-36-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 274.6 °C at 760 mmHg
• Flash Point: 119.9 °C
• Appearance: /
• Density: 1.184 g/cm³
• Vapor Pressure: 0.00535mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 3-methyl-2-benzofurancarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-methyl-2-benzofurancarboxylate(2076-36-0)
• EPA Substance Registry System: Methyl 3-methyl-2-benzofurancarboxylate(2076-36-0)

Safety Data

• Hazardous Substances Data: 2076-36-0(Hazardous Substances Data)

Usage

Uses

3-Methylbenzofuran-2-carboxylic Acid Methyl Ester acts as a reagent in the synthesis and SAR of highly selective MMP-13 Inhibitors, preparation of saframycin analogs for the treatment of cancer.

InChI:InChI=1/C11H10O3/c1-7-8-5-3-4-6-9(8)14-10(7)11(12)13-2/h3-6H,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 24673-56-1 3-methyl-1-benzofuran-2-carboxylic acid 
• 67-56-1 methanol 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 2256-86-2 3-methyl-1-benzofuran-2-carbonyl chloride 
• 77956-92-4 methyl 2-(2-acetylphenoxy)acetate 
• 118-93-4 o-hydroxyacetophenone 
• 124-38-9 carbon dioxide 
• 195830-41-2 1-iodo-2-(propa-1,2-dien-1-yloxy)benzene 
• 64908-64-1 2-phenoxyisoindol-1,3-dione 
• 98-80-6 phenylboronic acid 
• 5661-50-7 N-(phenoxy)acetamide 
• 23326-27-4 Methyl 2-butynoate 
• 4846-21-3 O-phenylhydroxylamine 

Downstream Products

• 55581-62-9 2-(hydroxymethyl)-3-methylbenzofuran 
• 1199-07-1 3-methylbenzofuran-2-carboxaldehyde 
• 58763-73-8 3-bromomethylbenzofuran-2-carboxylic acid methyl ester 

Relevant articles and documents

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Palladium-Catalyzed Intramolecular Arylative Carboxylation of Allenes with CO2 for the Construction of 3-Substituted Indole-2-carboxylic Acids

Arylative carboxylation of allenes proceeded in an intramolecular manner to afford the corresponding β,γ-unsaturated carboxylic acids in high yields using PdCl2/PAr3 (Ar = C6H4-p-CF3) and ZnEt2 under 1 atm of CO2. The intermediate of the cyclization/carboxylation sequence is thought to be a nucleophilic η1-allylethylpalladium, which reacts with CO2 at the γ-position of palladium. The products obtained could be efficiently converted into 3-substituted indole-2-carboxylate derivatives. One-pot synthesis of strychnocarpine, a β-carboline alkaloid, from the carboxylated product was also demonstrated.

BENZOFURAN ANILIDE HISTONE DEACETYLASE INHIBITORS

The present disclosure provides a compound of general Formula (I) having enzyme inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.