195875-07-1Relevant academic research and scientific papers
Synthetic oligonucleotide combinatorial libraries. 3. Synthesis of polyaminonucleosides
Godzina, Przemyslaw,Adrych-Rozek, Katarzyna,Markiewicz, Wojciech T.
, p. 2397 - 2414 (2007/10/03)
Synthesis of polyamino-2'deoxynucleosides was studied. A synthesis of 2'-deoxyadenosine and 2'-deoxyguanosine derivatives carrying a protected spermine moiety at N-6 and N-2 positions respectively is described using unprotected polyamines as substrates. T
Nucleotides: Part LV - Synthesis and Application of a Novel Linker for Solid-Phase Synthesis of Modified Oligonucleotides
Waldvogel, Siegfried R.,Pfleiderer, Wolfgang
, p. 46 - 58 (2007/10/03)
Various bifunctional amino-protecting groups such as the phthaloyl, succinyl, and glutaryl group were investigated as potential linker molecules for attachment to solid-support materials. Pentane-1,3,5-tricarboxylic acid 1,3-anhydride (16) offered the best properties and reacted with the amino groups of differently sugar-protected adenosine (see 20 and 22), cytidine (see 29), and guanosine derivatives (see 32) to the corresponding 2-(2-carhoxyethyl)glutaryl derivatives 23, 24, 30, and 33. The usefulness of the new linker-type molecules was demonstrated by the solid-support synthesis of the potentially antivirally active 3′-deoxyadenylyl-(2′-5′)-2′-adenylic acid 2′-{2-[(adenin-9-yl)methoxy]ethyl} ester (38) starting from the 2′-end with N6,N 6-[2-(2-carboxyethyl)glutaryl]-9-{{2-[(4,4′-dimethoxytrityl) oxy]ethoxy} methyl}adenine (12).
