259141-09-8

Upstream product

• 71-44-3 Spermine 
• 153527-28-7 5'-O-(4,4'-Dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2-fluoroinosine 
• 961-07-9 2'-Deoxyguanosine 
• 195875-07-1 6-O-(4-nitrophenylethyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine 
• 86137-72-6 2'-deoxy-O⁶-<2-(4-nitrophenyl)ethyl>guanosine 
• 132183-39-2 2-fluoro-O⁶-(2-(p-nitrophenyl)ethyl)-2'-deoxyinosine 
• 129184-64-1 3',5'-bis-O-trimethylsilyl-2'-deoxyguanosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 190506-33-3 3′,5′-O-bis(tert-butyldimethylsilyl)-O⁶-(p-nitrophenylethyl)-2′-deoxy-2-fluoroguanosine 
• 147299-48-7 3'-O,5'-O-bis(tert-butyldimethylsilyl)-O⁶-(2''-(4'''-nitrophenyl)ethyl)-2'-deoxyguanosine 
• 51549-35-0 3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 100-27-6 2-(4-nitrophenyl)ethanol 

Downstream Products

• 259141-10-1 5'-O-(4,4'-dimethoxytrityl)-6-O-(4-nitrophenylethyl)-2-N-[tris(N,N',N''-trifluoroacetyl)-4,9,13-triazatridecane-1-yl]-2'-deoxyguanosine 

Relevant academic research and scientific papers

Synthetic oligonucleotide combinatorial libraries. 3. Synthesis of polyaminonucleosides

Synthesis of polyamino-2'deoxynucleosides was studied. A synthesis of 2'-deoxyadenosine and 2'-deoxyguanosine derivatives carrying a protected spermine moiety at N-6 and N-2 positions respectively is described using unprotected polyamines as substrates. T

Synthesis and hybridization properties of oligonucleotides containing polyamines at the C-2 position of purines: A pre-synthetic approach for the incorporation of spermine into oligodeoxynucleotides containing 2-(4,9,13-Triazatridecyl)-2′-deoxyguanosine

We have developed a synthesis of spermine-containing oligonucleotides (ODN-sper) which allows incorporation of multiple polyamine residues. This approach was based on the pertrifluoroacetylated 5′DMT-dGsper phosphoramidite synthon. Its coupling yield with