88183-82-8

Basic information

• Product Name: 3',5'-O-[Tetrakis(1-Methylethyl)-1,3-disiloxanediyl]-guanosine
• Synonyms: 3',5'-O-[Tetrakis(1-Methylethyl)-1,3-disiloxanediyl]-guanosine;3',5'-O-[1,1,3,3-tetrakis(1-Methylethyl)-1,3-disiloxanediyl]-guanosine;3',5'-O-Tetraisopropyldisiloxane Guanosine;6H-Furo[3,2-f]-1,3,5,2,4-trioxadisilocin, guanosine deriv.
• CAS NO: 88183-82-8
• Molecular Formula: C₂₂H₃₉N₅O₅Si₂
• Molecular Weight: 525.74596
• Product Categories: Bases & Related Reagents;Nucleotides
• Mol File: 88183-82-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Solubility: Methanol
• CAS DataBase Reference: 3',5'-O-[Tetrakis(1-Methylethyl)-1,3-disiloxanediyl]-guanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-O-[Tetrakis(1-Methylethyl)-1,3-disiloxanediyl]-guanosine(88183-82-8)
• EPA Substance Registry System: 3',5'-O-[Tetrakis(1-Methylethyl)-1,3-disiloxanediyl]-guanosine(88183-82-8)

Safety Data

• Hazardous Substances Data: 88183-82-8(Hazardous Substances Data)

Usage

Chemical Properties

3',5'-O-[Tetrakis(1-Methylethyl)-1,3-disiloxanediyl]-guanosine is White Solid

Uses

3',5'-O-[Tetrakis(1-Methylethyl)-1,3-disiloxanediyl]-guanosine is used in the preparation of nucleotide analogs.

Upstream product

• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 961-07-9 2'-Deoxyguanosine 
• 69304-44-5 3',5'-O-1,1,3,3-tetraisopropyldisiloxan-1,3-diyl-guanosine 
• 88183-80-6 2'-O-(1-imidazolyl)thiocarbonyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine 

Downstream Products

• 195875-07-1 6-O-(4-nitrophenylethyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine 
• 157024-23-2 N-{9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-yl}-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionamide 
• 157024-22-1 3-[1-(2,4-Dinitro-phenyl)-1H-imidazol-4-yl]-N-{9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-yl}-propionamide 
• 172965-88-7 Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-oxo-2-phenylacetylamino-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 172965-87-6 5'-O-Dimethoxytrityl-2-N-phenylacetyl-2'-deoxyquanosine 
• 92447-25-1 N²-Phenylacetyl-2'-deoxyguanosine 
• 190192-14-4 N-[6-Oxo-9-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-6,9-dihydro-1H-purin-2-yl]-2-phenyl-acetamide 

Relevant articles and documents

Reactivity of nucleosides with a hydroxyl radical in non-aqueous medium

An experiment was conducted to demonstrate the reactivity of nucleosides with a hydroxyl radical (HO) in non-aqueous medium. Five nucleosides and three purine-derived lesions were taken as targets for HO attack. The reactivity with HO radical was determined by laser flash photolysis (LFP) of N-hydroxypyridine-2-thione (NPT) at 355 nm. Following an established kinetic model, the rate constants for the reaction between HO and the modified nucleobases were determined by using naphthalene as a standard. The values obtained for the silylated 2 -deoxyribonucleosides in acetonitrile are of the same order of magnitude and remarkably lower than diffusion control in this solvent, pointing to a similar reactivity pattern. The result confirmed that the reaction of a hydroxyl radical with 2'-deoxyribonucleosides is in general somewhat slower in acetonitrile than in water.

Low-temperature photosensitized oxidation of a guanosine derivative and formation of an imidazole ring-opened product

An organic-soluble guanosine derivative, 2′,3′,5′-O-(tert-butyldimethylsilyl)guanosine (1), was prepared and its photosensitized oxidation was carried out in several solvents at various temperatures. Singlet oxygen is the reactive oxidizing agent responsi

The Phenylacetyl Group - The First Amino Protecting Group That Can Be Removed Enzymatically from Oligonucleotides in Solution and on a Solid Support

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