Dinucleoside monophosphate analogues containing disulfide linkages

Article abstract of DOI:10.1016/S0040-4039(97)01542-6

The synthesis of two dinucleoside monophosphate analogues is described in which the 3'-O-P-O-5' phosphodiester linkage is replaced by either an isosteric 3'-C-S-S-5' or a shorter 3'-S-S-5' linkage. In both cases the -S-S- bond was formed through a disulfide exchange reaction using an activated S-nucleosidyl S-aryl disulfide and a suitably protected derivative of 5'-thiothymidine.