19598-07-3

Basic information

• Product Name: (1R,2R)-2,3-dihydro-1H-indene-1,2-diyl diacetate
• Synonyms: trans-Indan-1,2-diol, diacetate
• CAS NO: 19598-07-3
• Molecular Formula: C₁₃H₁₄O₄
• Molecular Weight: 234.2479
• Mol File: 19598-07-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 319.8°C at 760 mmHg
• Flash Point: 155.6°C
• Density: 1.2g/cm³
• Vapor Pressure: 0.000332mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: (1R,2R)-2,3-dihydro-1H-indene-1,2-diyl diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-2,3-dihydro-1H-indene-1,2-diyl diacetate(19598-07-3)
• EPA Substance Registry System: (1R,2R)-2,3-dihydro-1H-indene-1,2-diyl diacetate(19598-07-3)

Safety Data

• Hazardous Substances Data: 19598-07-3(Hazardous Substances Data)

Usage

General Description

"(1R,2R)-2,3-dihydro-1H-indene-1,2-diyl diacetate" is a chemical compound with the molecular formula C12H14O4. It is a diacetate ester derivative of 1,2-dihydro-1H-indene, which is a bicyclic organic compound. This chemical is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various drugs and pharmaceutical compounds. It is also used in organic synthesis as a reagent and building block for the preparation of other organic compounds. "(1R,2R)-2,3-dihydro-1H-indene-1,2-diyl diacetate" has applications in the production of pharmaceuticals, agrochemicals, and other fine chemicals.

Upstream product

• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 95-13-6 1-indene 
• 4370-02-9 cis-indane-1,2-diol 

Relevant articles and documents

B2pin2-Mediated Palladium-Catalyzed Diacetoxylation of Aryl Alkenes with O2 as Oxygen Source and Sole Oxidant

A novel palladium-catalyzed alkene diacetoxylation with dioxygen (O2) as both the sole oxidant and oxygen source is developed, which was identified by 18O-isotope labeling studies. Control experiments suggested that bis(pinacolato)diboron (B2pin2) played a dominant intermediary role in the formation of a C-O bond. This method performed good functional group tolerance with moderate to excellent yields, which could be successfully applied to the late-stage modification of natural products. Furthermore, an atmospheric pressure of dioxygen enhances the practicability of the protocol.

BF3·OEt2-promoted diastereoselective diacetoxylation of alkenes by PhI(OAc)2

Selective syn and anti diacetoxylations of alkenes have been achieved using a PhI(OAc)2/BF3·OEt2 system in the presence and absence of water, respectively. A broad range of substrates including electron-deficient alkenes (such as α,β-unsaturated esters) could be elaborated efficiently at room temperature with this methodology, furnishing the desired products in good to excellent yields and diastereoselectivity. In particular, a multigram-scale diastereoselective diacetoxylation of methyl cinnamate (5.00 g) was also accomplished in a few hours, maintaining the same efficiency as small-scale reaction. This novel methodology provides an alternative approach for the preparation of various 1,2-diols.

Efficient diacetoxylation of alkenes via Pd(II)/Pd(IV) process with peracetic acid and acetic anhydride

A palladium-catalyzed diacetoxylation of alkenes in the presence of peracetic acid and acetic anhydride was developed to produce diacetates efficiently and diastereoselectively. Due to its mild conditions, this method was suitable for a broad range of substrates encompassing conjugated and nonconjugated olefins.