1960-59-4

Usage

Uses

Used in Pharmaceutical Industry:
2-nitro-1-phenoxy-4-(trifluoromethyl)benzene is used as a building block in the synthesis of various pharmaceuticals for its potential applications in the treatment of various diseases, such as cancer and inflammatory disorders, due to its anti-inflammatory and anticancer properties.
Used in Agrochemical Industry:
2-nitro-1-phenoxy-4-(trifluoromethyl)benzene is used as a building block in the synthesis of various agrochemicals.
Used in Materials Industry:
2-nitro-1-phenoxy-4-(trifluoromethyl)benzene is used as a building block in the synthesis of various materials.
Used in Environmental Research:
2-nitro-1-phenoxy-4-(trifluoromethyl)benzene is used as a potential environmental pollutant and is categorized as a hazardous substance due to its toxic effects on aquatic organisms. Further research is needed to fully understand its potential applications and environmental impact.

Upstream product

• 139-02-6 sodium phenoxide 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 108-95-2 phenol 

Downstream Products

• 50594-30-4 2-Fluoro-1-phenoxy-4-trifluoromethyl-benzene 
• 50594-26-8 2-Fluoro-1-(4-nitro-phenoxy)-4-trifluoromethyl-benzene 
• 42874-27-1 2-Bromo-1-(4-nitro-phenoxy)-4-trifluoromethyl-benzene 
• 182565-78-2 N-butyl-2-nitro-4-(trifluoromethyl)aniline 
• 1692-79-1 1-(2-nitro-4-(trifluoromethyl)phenyl)piperidine 
• 40832-82-4 1-(2-nitro-4-(trifluoromethyl)phenyl)pyrrolidine 
• 50594-29-1 2-Phenoxy-5-trifluoromethyl-phenylamine 

Relevant academic research and scientific papers

Pd-Catalyzed Denitrative Intramolecular C-H Arylation

A Pd-catalyzed intramolecular C-H arylation of nitroarenes has been developed. Nitroarenes bearing tethered aryl groups at the ortho-position can be readily prepared in one step from 2-halonitroarenes by a nucleophilic aromatic substitution (SNAr). Under Pd/BrettPhos catalysis, activations of the C-NO2 bond as well as the C-H bond on arenes generated the corresponding biaryl linkage in moderate to excellent yields.

The effects of ring substituents and leaving groups on the kinetics of SNAr reactions of 1-halogeno- and 1-phenoxy-nitrobenzenes with aliphatic amines in acetonitrile

Rate constants are reported for the reactions of a series of 1-chloro-, 1-fluoro- and 1-phenoxy-nitrobenzenes activated by CF3 or CN groups or by ring-nitrogen with n-butylamine, pyrrolidine or piperidine in acetonitrile. The results are compar

Tris(polyoxaalkyl)amines (Trident), a New Class of Solid-Liquid Phase-Transfer Catalysts

A new class of solid-liquid phase-transfer catalysts has been prepared.These tris(polyoxaalkyl)amines (I) are designed to obtain the best balance between straightforward synthesis (cheap starting materials), high activity, easy recovery, and low toxicity.The catalysts are synthesized from ethylene glycols by a simple one-step method in yields in the range of 65-81percent.They show high catalytic effects in aliphatic nucleophic substitutions and aromatic nucleophilic substitutions on activated and unactivated molecules.In the Ullman synthesis (a new PTC reaction) there is a synergic effect of anionic activation by tridents and by copper salts.Reactions have been carried out at temperatures up to 180 deg C without evidence of decomposition of the tris(polyoxaalkyl)amines. The behavior and catalytic activity of these catalysts are discussed.

THE SALT-FREE SYNTHESIS OF ARYL ETHERS USING METHYL TRICHLOROACETATE

Metyl trichloroacetate is an effective reagent for salt-free synthesis of aryl ethers and anisoles from phenols.