182565-78-2Relevant articles and documents
Synthesis of substituted diphenylamines under phase transfer catalysis
Durantini, Edgardo N.,Chiacchiera, Stella M.,Silber, Juana J.
, p. 3849 - 3858 (1996)
A convenient procedure for the synthesis of N-[trifluoromethyl)nitrphenyl] substituted anilines by means of a chloro-substitution reaction under conditions of phase-transfer catalysis (PTC) is reported. The ipso-substitution product is obtained with high
Tuning Flavin-Based Photocatalytic Systems for Application in the Mild Chemoselective Aerobic Oxidation of Benzylic Substrates
Tolba, Amal Hassan,Vávra, Franti?ek,Chudoba, Josef,Cibulka, Radek
supporting information, p. 1579 - 1585 (2019/12/24)
New flavin-based photocatalytic systems used for chemoselective aerobic visible-light oxidations have been developed by tuning the flavin structure and reaction conditions. 1,3-Dimethyl-7-trifluoromethylalloxazine (2) and 10-butyl-3-methyl-7-trifluoromethylisoalloxazine (3) were shown to mediate the selective oxidation of benzyl alcohols to form aldehydes in the presence of Cs2CO3. Flavin 3 was superior in the oxidation of toluene derivatives to form aldehydes in the presence of trifluoroacetic acid. On the other hand, photooxidations provided by ethylene-bridged quaternary flavinium salt 1 gave the corresponding carboxylic acids. The usefulness of the developed catalytic systems using 1–3 was also demonstrated in the oxidation of secondary benzylic and aliphatic alcohols, and benzylic methylene groups to form the corresponding ketones. The systems have the advantage of a broad substrate scope and metal-free conditions, which distinguish them from the previously reported flavin photooxidation reactions.
Synthesis of o-Nitroarylamines via Ipso Nucleophilic Substitution of Sulfonic Acids
Manne, Srinivasa Rao,Chandra, Jyoti,Mandal, Bhubaneswar
supporting information, p. 636 - 639 (2019/01/21)
A mild, efficient, and eco-friendly method for the synthesis of o-nitroarylamine from o-nitroaryl sulfonic acid via ipso nucleophilic aryl substitution by amine is described. The products have been obtained with good yields at room temperature without the assistance of any metal, activating agent, or toxic oxidant. This method is useful for racemization-free synthesis of N-aryl amino acid esters.
Cs2CO3-Promoted Direct N-Alkylation: Highly Chemoselective Synthesis of N-Alkylated Benzylamines and Anilines
Castillo, Juan-Carlos,Orrego-Hernández, Jessica,Portilla, Jaime
, p. 3824 - 3835 (2016/08/20)
Herein is described an efficient and chemoselective method for the synthesis of diversely substituted secondary amines in yields up to 98 %. Direct mono-N-alkylation of primary benzylamines and anilines with a wide range of alkyl halides is promoted by a cesium base in the absence of any additive or catalyst. The basicity and solubility of cesium carbonate in anhydrous N,N-dimethylformamide not only enables mono-N-alkylation of primary amines but also suppresses undesired dialkylation of the desired amines.
The effects of ring substituents and leaving groups on the kinetics of SNAr reactions of 1-halogeno- and 1-phenoxy-nitrobenzenes with aliphatic amines in acetonitrile
Crampton, Michael R.,Emokpae, Thomas A.,Isanbor, Chukwuemeka
, p. 1378 - 1383 (2008/09/18)
Rate constants are reported for the reactions of a series of 1-chloro-, 1-fluoro- and 1-phenoxy-nitrobenzenes activated by CF3 or CN groups or by ring-nitrogen with n-butylamine, pyrrolidine or piperidine in acetonitrile. The results are compar
Imidazopyridinone derivatives and their use as phosphodiesterase inhibitors
-
, (2008/06/13)
A compound (Ia): wherein the variables are defined in the specification, its prodrug or a pharmaceutically acceptable salt thereof useful in the treatment of angina, hypertension etc.
Synthesis and antimicrobial activity of some new 2-phenyl-N-substituted carboxamido-1H-benzimidazole derivatives
Goeker, Hakan,Tuncbilek, Meral,Suezen, Sibel,Kus, Canan,Altanlar, Nurten
, p. 148 - 152 (2007/10/03)
Some 1H-benzimidazole-carboxamide derivatives were prepared and their antimicrobial activities against Staphyloccus aureus, Escherichia coli and Candida albicans evaluated. Compounds 18, 22, and 25 exhibited the best activity against Candida albicans.
Design and syntheses of a series of novel serotonin3 antagonists
Hori,Suzuki,Yamamoto,Nakajima,Ozaki,Ohtaka
, p. 1832 - 1841 (2007/10/02)
From a structural comparison study between serotonin and serotonin3 (5- HT3) antagonists using a two-dimensional grid template composed of regular hexagons, we deduced structural modification patterns from agonists to antagonists, an
