1961-73-5

Usage

Uses

Used in Pharmaceutical Industry:
D-Glycero-D-Mannoheptose is used as a component in the pharmaceutical industry for the development of drugs targeting gram-negative bacteria, such as Salmonella typhimurium. Its presence in the O-antigenic lipopolysaccharide makes it a potential candidate for the creation of antibiotics or vaccines.
Used in Research and Development:
D-Glycero-D-Mannoheptose is used as a research compound for studying the structure and function of bacterial cell walls, as well as the interactions between bacteria and their hosts. This can lead to a better understanding of bacterial pathogenesis and the development of new strategies to combat bacterial infections.
Used in Chemical Synthesis:
As a monosaccharide, D-Glycero-D-Mannoheptose can be used as a building block in the synthesis of more complex carbohydrates and other biomolecules. This can have applications in various industries, including pharmaceuticals, biotechnology, and materials science.

Upstream product

• 5329-44-2 D-glycero-D-manno-heptonic acid-4-lactone 
• 130930-35-7 1-deoxy-1-nitro-D-glycero-D-manno-heptitol 
• 1990-29-0 D-altrose 
• 15397-08-7 D-glycero-D-galacto-heptono-1,4-lactone 
• 14199-89-4 1?deoxy?1?nitro?D?glycero?D?galacto?heptitol 
• 7664-93-9 sulfuric acid 
• 3458-28-4 D-Mannose 

Downstream Products

• 158568-55-9 1-phenyl-3-α-D-threofuranosylpyrazolo<3,4-b>quinoxaline 
• 488-38-0 volemitol 
• 3615-44-9 D-mannoheptulose 
• 110439-22-0 D-erythro-L-gluco-octonic acid-(N'-phenyl-hydrazide) 
• 68832-85-9 1-phenyl-3-(D-lyxo-tetritol-1-yl)pyrazolo<3,4-b>quinoxaline 

Relevant academic research and scientific papers

The core oligosaccharide component from mannheimia (pasteurella) haemolytica serotype A1 lipopolysaccharide contains L-glycero-D-manno-and D-glycero-D-manno-heptoses: Analysis of the structure and conformation by high-resolution NMR spectroscopy

Previous studies from our laboratory have indicated that the lipopolysaccharide (LPS) from Mannheimia haemolytica serotype A1 contains both L-glycero-D-manno-heptose and D-glycero-D-manno-heptose residues. NMR methods making use of 1D 1H selective excitation and 2D (1H, 13C) and (1H, 31P) heteronuclear experiments were used for the structural determination of the major core oligosaccharide components of the deacylated low-molecular-mass LPS obtained following sequential treatment with anhydrous hydrazine and aq KOH. The core oligosaccharide region was found to be composed of a branched octasaccharide linked to the deacylated lipid A moiety via a 3-deoxy-4-phospho-D-manno-oct-2-ulosonate residue having the structure, α -D-Glc p-(1↓6 β-D -Galp-(1-7)-D -α-D -Hepp-(1-6)-D -α-D -Hepp-(1-6)-β-D -Glcp-(1-4)-L -α-D -Hepp-(1→3↑L -α-D -Hepp-(1-2)-L -α-D -Hepp-(1 Heterogeneity was found to be present at several linkages. NMR methods were devised to distinguish between the diastereomeric forms of the heptose residues. Synthesized monosaccharides of L-D- and D-D-heptose were used as model compounds for analysis of the 1H and 13C NMR chemical shifts and proton coupling constants. Molecular modeling using a Monte Carlo method for conformational analysis of saccharides was used to determine the conformation of the inner core of the oligosaccharide and to establish the stereochemical relationships between the heptoses.

STRUCTURAL STUDIES OF THE ANTIGENIC POLYSACCHARIDE OF EUBACTERIUM SABURREUM, STRAIN T27

The antigenic polysaccharide produced by Eubacterium saburreum, strain T27, is a homoglycan composed of D-glycero-D-galacto-heptose (Hep) residues having a nonasaccharide repeating-unit with the structure 6)-4)>-β-Hepp-(1>36)-2), α-Hepf-(14)>-β-Hepp-(1.The polysaccharide contains acetyl groups linked to O-2 (except to the 2,4,6-linked heptopyranosyl residue), O-3 and O-7 of part of both heptopyranosyl and heptofuranosyl residues.The assignment of an acetyl group at O-3 of part of the terminal heptofuranosyl and 4,6-linked heptopyranosyl groups is tentative.