1963-30-0

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dimethylcinnamic acid is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its chemical structure allows for the development of new drugs and the modification of existing ones, contributing to advancements in medicine and healthcare.
Used in Cosmetic and Skincare Industry:
2,3-Dimethylcinnamic acid is used as an active ingredient in cosmetic and skincare products for its anti-inflammatory, antioxidant, and UV-absorbing properties. It helps to soothe and protect the skin, making it a valuable component in formulations for skincare products, sunscreens, and other beauty applications.
Used in Organic Chemistry Research:
2,3-Dimethylcinnamic acid is used as a versatile building block in organic chemistry research. Its unique structure allows for the exploration of new chemical reactions and the synthesis of novel organic compounds, contributing to the advancement of scientific knowledge and the development of new materials and applications.

Upstream product

• 141-82-2 malonic acid 
• 5779-93-1 2,3-dimethylbenzaldehyde 
• 15012-36-9 methyl 2,3-dimethylbenzoate 
• 576-23-8 2,3-dimethylbromobenzene 
• 13651-14-4 (2,3-dimethylphenyl)methanol 
• 95-47-6 o-xylene 
• 79-10-7 acrylic acid 
• 87-59-2 2,3-Dimethylaniline 

Downstream Products

• 37678-61-8 4,5-Dimethyl-indan-1-on 
• 23288-07-5 6,7-dimethyl-1H-indene 

Relevant academic research and scientific papers

Photoinduced Regioselective Olefination of Arenes at Proximal and Distal Sites

The Fujiwara-Moritani reaction has had a profound contribution in the emergence of contemporary C-H activation protocols. Despite the applicability of the traditional approach in different fields, the associated reactivity and regioselectivity issues had

Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides

Abstract: A series of amides based on (2S)-cyanopyrrolidine and α, β-unsaturated aryl- and hetarylcarboxylic acids have been synthesized. The dependence of the hypoglycemic activity of compounds on the structure of the aromatic fragment has been studied in the oral glucose tolerance test in mice. Amides based on (E)-3-phenylprop-2-enoic and (E)-3-(4-methoxyphenyl)prop-2-enoic acids and (2S)-cyanopyrrolidine have been shown to significantly reduce blood glucose levels in mice. The observed hypoglycemic effect at a dose of 10 mg/kg is comparable to the effect of hypoglycemic drug vildagliptin.

Aromatic Spiranes XX [1]: Syntheses of Dimethylsubstituted 2-Carboxymethyl-indan-1-ones and Benzylchlorides as Synthones for Syntheses of di- to tetramethylsubstituted Spirobiindandiones

The isomeric dimethyl methylbenzoates 5, obtained from the bromides via Grignard reactions with dimethylcarbonate, were reduced with LiAlH4 to the hydroxymethyl derivatives 6. The latter were then transformed both to the benzylchlorides 7 (with SOCl2) and to the aldehydes 8 (with pyridinium chlorochromate). Knoevenagel-Doebner reaction of 8 afforded the acrylic acids 9 which (after hydrogenation to 11) were cyclized to the desired indanones 12 with polyphosphoric acid. On the other hand, 12c and 12e were prepared from dimethyl 3-chloropropiophenone (14) by warming with sulfuric acid. After NaH-catalyzed reaction with dimethylcarbonate, the indanones 12 gave the ketoesters 15 which then could be hydrogenated to the indanes 16. All reactions proceeded with satisfactory to excellent yields (60-90%).