196303-53-4Relevant academic research and scientific papers
Racemic, yet diastereomerically pure azido acids as both γ-turn and inverse γ-turn mimetics for solid-phase peptide synthesis
Schmidt, Boris,Kühn, Christian
, p. 1240 - 1242 (2007/10/03)
The chemoselective arylation of cyclohexane-1,3,5-tricarboxylate derivatives gave access to ketodiesters. Corey's variation of Mukayama's 2-mercaptopyridine activation was superior to acid chlorides and Weinreb amides. The obtained meso-diesters were desymmetrized by L-Selectride and further elaborated to azido acids. These azido acids (e.g. 7) are novel γ-turn templates for solid-phase synthesis of peptides such as 8a and 8b.
Fmoc protected peptide mimetic based on a cyclohexane framework and incorporation into angiotensin II
Kuehn, Christian,Lindeberg, Gunnar,Gogoll, Adolf,Hallberg, Anders,Schmidt, Boris
, p. 12497 - 12504 (2007/10/03)
1,3,5-syn substituted cyclohexane based amino acids have been prepared and incorporated into synthetic peptides to serve as scaffold mimicking the Val-Tyr-Ile sequence of angiotensin II. The conformationally constrained tripeptide mimetic holds potential
